ID E7F965_DANRE Unreviewed; 829 AA.
AC E7F965; A0A8N7T5S3;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Achaete-scute homolog 1b {ECO:0000313|Ensembl:ENSDARP00000108118};
DE SubName: Full=Malignant fibrous histiocytoma-amplified sequence 1-like isoform X1 {ECO:0000313|RefSeq:XP_688932.3};
GN Name=si:ch211-210p4.6 {ECO:0000313|RefSeq:XP_688932.3,
GN ECO:0000313|ZFIN:ZDB-GENE-161017-126};
GN Synonyms=ascl1b {ECO:0000313|ZFIN:ZDB-GENE-980526-174};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000108118};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000108118}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108118};
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000108118, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108118};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_688932.3}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_688932.3};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX088691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_688932.3; XM_683840.7.
DR STRING; 7955.ENSDARP00000108118; -.
DR PaxDb; 7955-ENSDARP00000108118; -.
DR Ensembl; ENSDART00000126991; ENSDARP00000108118; ENSDARG00000009702.
DR Ensembl; ENSDART00000126991.4; ENSDARP00000108118.1; ENSDARG00000009702.10.
DR GeneID; 560440; -.
DR AGR; ZFIN:ZDB-GENE-161017-126; -.
DR AGR; ZFIN:ZDB-GENE-980526-174; -.
DR ZFIN; ZDB-GENE-980526-174; ascl1b.
DR ZFIN; ZDB-GENE-161017-126; si:ch211-210p4.6.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_341929_0_0_1; -.
DR OrthoDB; 36592at2759; -.
DR PhylomeDB; E7F965; -.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000009702; Expressed in zone of skin and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR032171; COR.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF40; MALIGNANT FIBROUS HISTIOCYTOMA-AMPLIFIED SEQUENCE 1-LIKE ISOFORM X1; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08477; Roc; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 207..426
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
SQ SEQUENCE 829 AA; 96231 MW; 441CD4F0D0016EC4 CRC64;
MAQINGNPNT QNEDDYSGKK LKALPRQLLQ RGADAVKVEL QRNRLRQITD ISQLTNLKEL
NLSRNEITDF PVEIRALRQL KTLYLNQNNI KTIPENVFPS LEKLNFLKLS TNRLEKLPSD
ISRCQDLTYL NLSNNCLKDL YPLVGLSRLK ELYIERNQLA ELPDRLFQNS SLNVFKANGN
PLRKPPGEVC AGGLKDIQNY FAMLEANAPD VYTVKTMFLG NSMAGKSTLC RSLKEGCPVQ
VAEADRTVGI EISEFTVRDG SDSIRFLFWD FAGQEEYYIT HHVFITPQAF VILAINLSSY
KMDEATFKEN VVFWITNLQL QIPDSVVLLV GTHVDQCQDE NEVKKKKEHI EEQVKKMLDT
HTVNLEQRRK NLQEVDDPSS NSEQINQIER LTEYKLKVLE LVPIDCTKPA DIDKLKTRIK
AEVLNKDTFP SIEQTLPRSY YEVENHIQEL LENGDIPEHG VVSQDVLLCE LKNRLTTLDD
DKLKLILQYL HRIGVIMWYK EIPELQESLF VKPSFLISLF KTVVRHDLVQ ELNKISSAQR
KSENALVVDK KRWIRDYEER ASLSNVAIRI LVRTELEKIY ESADKELIEE VVGSKNKEGS
LLSLLKHFDV CLSTKHNSGL NPKANEFCPK KDWVPSNPTV YELDACMFPS FLPDNMQVER
EWGSNSSEDL NIRVYLMPEI PHGFFHRLVV RTCSFYSPFW IGKDQCMLCC GDKRVLLRER
RFDEDQFIEI RCKESALETS EDIQKAWKVI KEIMKRLDRL KEQWQGLCQK VHSPCKAQDC
EDFFEWTDWH DWLEDSETNR FNLGLEEKTT CRNGHQRRTE LLFPRTPDA
//
