ID E7FAE2_DANRE Unreviewed; 325 AA.
AC E7FAE2; A0A8N7UT57; X1WDA9;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=PI-PLC X domain-containing protein 1 {ECO:0000313|Ensembl:ENSDARP00000108016, ECO:0000313|RefSeq:XP_691942.1};
GN Name=plcxd1 {ECO:0000313|Ensembl:ENSDARP00000108016,
GN ECO:0000313|RefSeq:XP_691942.1, ECO:0000313|ZFIN:ZDB-GENE-131127-240};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000108016};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000108016}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108016};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000108016, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108016};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_691942.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_691942.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX323016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_691942.1; XM_686850.6.
DR STRING; 7955.ENSDARP00000128208; -.
DR PaxDb; 7955-ENSDARP00000128208; -.
DR Ensembl; ENSDART00000126379.3; ENSDARP00000108016.3; ENSDARG00000088798.4.
DR Ensembl; ENSDART00000156546.3; ENSDARP00000128208.1; ENSDARG00000088798.4.
DR GeneID; 563489; -.
DR KEGG; dre:563489; -.
DR AGR; ZFIN:ZDB-GENE-131127-240; -.
DR CTD; 55344; -.
DR ZFIN; ZDB-GENE-131127-240; plcxd1.
DR eggNOG; KOG4306; Eukaryota.
DR HOGENOM; CLU_051926_0_0_1; -.
DR OMA; VMSTYPA; -.
DR OrthoDB; 21624at2759; -.
DR TreeFam; TF314457; -.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000088798; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd08616; PI-PLCXD1c; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR042158; PLCXD1/2/3.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR PANTHER; PTHR13593:SF131; PI-PLC X DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR13593; UNCHARACTERIZED; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR SMART; SM00148; PLCXc; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 28..200
FT /note="Phosphatidylinositol-specific phospholipase C X"
FT /evidence="ECO:0000259|SMART:SM00148"
SQ SEQUENCE 325 AA; 37450 MW; 5A4FDF5BE87F1D99 CRC64;
MTSEVSQVSL SELPMDNWMA HLPSALWDTP ICYMAIPGSH NAITYCLDKN DRSPVDLTQP
DMLQKLDKYM KPIIRPFVYK WAIAQESCIR EQLDCGVRYC DLRIAHRPND RSNDLYFYHG
VYTTITVETV LKEIREWLDV HPKEVVILSF SHFLGLSQEL HSLLVSTIKS VFDSKLCPKM
ERVTLRKLWS EGHQVIVSYE HNTANCNREL WSHIPYWWAN KSKAEALIEE FERRKQNGRP
GGFFVTGINL TEDLKYICSH PTESLKDMVM STYPTLLSWV KQQKPGSNTG SLNIIAGDFV
TESQFIPTVI ALNENLLNRT ILPQP
//
