GenomeNet

Database: UniProt
Entry: E7FB26_DANRE
LinkDB: E7FB26_DANRE
Original site: E7FB26_DANRE 
ID   E7FB26_DANRE            Unreviewed;       375 AA.
AC   E7FB26;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   16-OCT-2019, entry version 68.
DE   SubName: Full=E74-like factor 3 (ets domain transcription factor, epithelial-specific ) {ECO:0000313|Ensembl:ENSDARP00000101728};
GN   Name=elf3 {ECO:0000313|Ensembl:ENSDARP00000101728,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-8760};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000101728, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000101728}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101728};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000101728, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101728,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; CU695132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU856139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_002666146.1; XM_002666100.3.
DR   Ensembl; ENSDART00000113795; ENSDARP00000101728; ENSDARG00000077982.
DR   GeneID; 560869; -.
DR   KEGG; dre:560869; -.
DR   CTD; 1999; -.
DR   ZFIN; ZDB-GENE-030131-8760; elf3.
DR   eggNOG; KOG3804; Eukaryota.
DR   eggNOG; ENOG4111K4J; LUCA.
DR   GeneTree; ENSGT00940000158955; -.
DR   KO; K09429; -.
DR   OrthoDB; 837296at2759; -.
DR   PhylomeDB; E7FB26; -.
DR   Proteomes; UP000000437; Chromosome 22.
DR   Bgee; ENSDARG00000077982; Expressed in 18 organ(s), highest expression level in pharyngeal gill.
DR   ExpressionAtlas; E7FB26; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd08537; SAM_PNT-ESE-1-like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR042693; Elf-3_PNT.
DR   InterPro; IPR033074; Elf3.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF13; PTHR11849:SF13; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN       35    122       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      280    362       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      206    273       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    206    241       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    242    273       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   375 AA;  42760 MW;  B963C1EDC6C3F50B CRC64;
     MASSELSLIL NNANANLYPE PQASLLSMCR PPHLSEITFN SNSTLGSWDQ VNPQMWSRQN
     VLEWIGFHVE ESRFDAGLLN LNYCTMDGLT LCATSKEALM SMFGPELGNL LHHSLESLKA
     RYVNDLSENT VLSESEFELL DNILQNSFPS MHGPGLGPLL ETVVVQSTIP TDNSDAKYSY
     FDEYTSQLTP ESDHGYDSLT ESFQSSHAGS FLNPSSPESN SSDSDPEYSE TPYSISSKNF
     SKQEPEKTKR GRGRPPKLRD SDGFDHFIQS KKSKHAPRGT HLWEFIRDIL IHPEQNQGLM
     KWEDRRDGVF KFLKSEAVAQ LWGQKKKNSS MTYEKLSRAM RYYYKREILE RVDGRRLVYK
     FGKNSTGWRI EETGY
//
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