ID E7FBH4_DANRE Unreviewed; 482 AA.
AC E7FBH4; A0A8M1P5X1;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Interferon-induced protein with tetratricopeptide repeats {ECO:0000313|EMBL:AID69087.1, ECO:0000313|Ensembl:ENSDARP00000126820};
GN Name=ifit10 {ECO:0000313|Ensembl:ENSDARP00000126820,
GN ECO:0000313|RefSeq:NP_001287801.1, ECO:0000313|RefSeq:XP_017213963.1,
GN ECO:0000313|ZFIN:ZDB-GENE-121214-248};
GN Synonyms=IFIT12B {ECO:0000313|RefSeq:NP_001287801.1,
GN ECO:0000313|RefSeq:XP_017213963.1}, si:dkey-26g8.11
GN {ECO:0000313|RefSeq:NP_001287801.1,
GN ECO:0000313|RefSeq:XP_017213963.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AID69087.1};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000126820, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000126820};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|RefSeq:NP_001287801.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23818968;
RA Liu Y., Zhang Y.B., Liu T.K., Gui J.F.;
RT "Lineage-specific expansion of IFIT gene family: an insight into
RT coevolution with IFN gene family.";
RL PLoS ONE 8:E66859-E66859(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000126820}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000126820};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001287801.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24683187;
RA Briolat V., Jouneau L., Carvalho R., Palha N., Langevin C., Herbomel P.,
RA Schwartz O., Spaink H.P., Levraud J.P., Boudinot P.;
RT "Contrasted innate responses to two viruses in zebrafish: insights into the
RT ancestral repertoire of vertebrate IFN-stimulated genes.";
RL J. Immunol. 192:4328-4341(2014).
RN [5] {ECO:0000313|EMBL:AID69087.1, ECO:0000313|RefSeq:NP_001287801.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24950240;
RA Varela M., Diaz-Rosales P., Pereiro P., Forn-Cuni G., Costa M.M., Dios S.,
RA Romero A., Figueras A., Novoa B.;
RT "Interferon-induced genes of the expanded IFIT family show conserved
RT antiviral activities in non-mammalian species.";
RL PLoS ONE 9:E100015-E100015(2014).
RN [6] {ECO:0000313|RefSeq:NP_001287801.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [7] {ECO:0000313|RefSeq:NP_001287801.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28789986;
RA Pereiro P., Forn-Cuni G., Dios S., Coll J., Figueras A., Novoa B.;
RT "Interferon-independent antiviral activity of 25-hydroxycholesterol in a
RT teleost fish.";
RL Antiviral Res. 145:146-159(2017).
RN [8] {ECO:0000313|RefSeq:NP_001287801.1, ECO:0000313|RefSeq:XP_017213963.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_017213963.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the IFIT family.
CC {ECO:0000256|ARBA:ARBA00038336}.
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DR EMBL; BX000534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF418360; AID69087.1; -; mRNA.
DR RefSeq; NP_001287801.1; NM_001300872.1.
DR RefSeq; XP_017213963.1; XM_017358474.2.
DR STRING; 7955.ENSDARP00000126820; -.
DR PaxDb; 7955-ENSDARP00000126820; -.
DR Ensembl; ENSDART00000152678.2; ENSDARP00000126820.1; ENSDARG00000007467.10.
DR GeneID; 567441; -.
DR KEGG; dre:567441; -.
DR AGR; ZFIN:ZDB-GENE-121214-248; -.
DR CTD; 567441; -.
DR ZFIN; ZDB-GENE-121214-248; ifit10.
DR eggNOG; KOG1124; Eukaryota.
DR HOGENOM; CLU_043482_1_0_1; -.
DR OMA; WIYYHMD; -.
DR OrthoDB; 5401272at2759; -.
DR TreeFam; TF342671; -.
DR Proteomes; UP000000437; Chromosome 12.
DR Bgee; ENSDARG00000007467; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IDA:ZFIN.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10271; INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS; 1.
DR PANTHER; PTHR10271:SF29; INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS-RELATED; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 2.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 252..285
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 435..468
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 482 AA; 56387 MW; 8027005FCC5CA486 CRC64;
MTSDVSSMEA DRALRTKLHQ LECHFTWALI KDDIDINDLL NRLEEQINLD LEKKERLART
YSALAYVQYL LGFHEKAHQS LMTSKKLHIE SHGDEFYRTL IVTYGNLAWL NYHMKNYTEC
ESYLNSLQRI NETSPAEFSS IPEVLGEKGW TFLKFSRKYY DGAKECFRKA VELEPEEPEW
HTGYAIALYR TEFESTVLED SATVKQLRLA IEMNPDDDVL KVLLSLRLIV YKRYGEAESW
VEKALEKSPD HPHVMRYVGK FFRNKGCVDR SIDLLKRALE RSPNSSFIHH QLALCYKYKK
IQVLQEQSHH ARGSRVQQLR DQCIFHLEKA TSLTTSFISA MSDLALQYGE NGDIPRAEEL
FQVTFKIAKE KNDGLHVVNY YYAEYQLYCH RCEPLAVQHY MECLKMCPKS VEGRISSTRM
KKTAEKWIDR KSQEGKAYGM LAFLHKVKGE IAQAIECYEK ALSYEDNNEF LRNLRELRLS
LL
//
