ID E7FE33_DANRE Unreviewed; 1044 AA.
AC E7FE33; A0A8M9QG07;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=FERM, RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSDARP00000129410};
DE SubName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 2 isoform X2 {ECO:0000313|RefSeq:XP_021332790.1};
GN Name=farp2 {ECO:0000313|Ensembl:ENSDARP00000129410,
GN ECO:0000313|RefSeq:XP_021332790.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-2993};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000129410};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000129410, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129410};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000129410}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129410};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [3] {ECO:0007829|PDB:6D21}
RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 49-380.
RX PubMed=29992992; DOI=10.1038/s41598-018-28692-4;
RA Kuo Y.C., He X., Coleman A.J., Chen Y.J., Dasari P., Liou J., Biederer T.,
RA Zhang X.;
RT "Structural analyses of FERM domain-mediated membrane localization of
RT FARP1.";
RL Sci. Rep. 8:10477-10477(2018).
RN [4] {ECO:0000313|RefSeq:XP_021332790.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021332790.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX957353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU467043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001922658.2; XM_001922623.4.
DR RefSeq; XP_021332790.1; XM_021477115.1.
DR PDB; 6D21; X-ray; 2.00 A; A=49-380.
DR PDBsum; 6D21; -.
DR STRING; 7955.ENSDARP00000129410; -.
DR PaxDb; 7955-ENSDARP00000129410; -.
DR Ensembl; ENSDART00000153595; ENSDARP00000129410; ENSDARG00000016429.
DR Ensembl; ENSDART00000153595.3; ENSDARP00000129410.1; ENSDARG00000016429.11.
DR AGR; ZFIN:ZDB-GENE-030131-2993; -.
DR ZFIN; ZDB-GENE-030131-2993; farp2.
DR eggNOG; KOG3531; Eukaryota.
DR HOGENOM; CLU_012301_0_0_1; -.
DR OMA; HKHMPED; -.
DR PhylomeDB; E7FE33; -.
DR Reactome; R-DRE-399955; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
DR Reactome; R-DRE-9013149; RAC1 GTPase cycle.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000016429; Expressed in presomitic mesoderm and 25 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6D21}; Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E7FE33};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 51..331
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 533..724
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 753..850
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 927..1024
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 638..665
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 120152 MW; 8173E1AF265D4520 CRC64;
MGEIEGSYRS LQTPAGSRLG GQHNTGISTL EPGQSLSSAM GAGGKGHNKG LQIRVQGLDE
AQEFYELESK ADGQLLLSDV FRRINLIESD YFGLEFQNLQ MNWVWLDPSK LIVKQVRRPM
NTLFRLSVKF FPPDPGQLQE EFTRYLFSLQ IKRDLLDGRL SCTENTAALL ASHLVQSEIG
DYDDLADREF LKMNKLLPCQ EHVQEKIMEL HRRHTGQTPA ESDFQVLEIA RKLEMFGVRF
HPAADREGTK INLAVAHMGL QVFQGHTKIN TFNWSKIRKL SFKRKRFLIK LHPEVHGPHQ
DTLEFLMGSR DQCKIFWKNC VEHHSFFRLL DQPQPKSKAI FFSRGSSFRY SGRTQKQLVE
YVRDSGLRRT PYQRRNSKIR MSTRSLASDV PKQNLSFNDS LRTHIPPSSI TASFQSLHAP
SVSMRAETPN QLLHLHQTQH QPLRAPSPMK QDPIKTNSQS TYAFPDSIAI DSPQLSPFND
KGPLCLSPSF QMSTLSLPGQ APSPLQSPIL NEVGTARLDE DEEGRRKRYP TDKAYFIAKE
ILTTERTYLK DLEVITVWFR SAVIKENAMP EGLMTLLFSN IDPIYEFHRG FLKEIDQRLA
LWEGRSNAHV KGDYQRIGDV MLRNMCSLKE FTGYLQKHDE VLTELEKATK RVKKLETVYK
EFELQKVCYL PLNTFLLKPI QRLMHYKLIL ERLCKHYSPQ HRDYDDCKEA LKEVAEIATQ
LQSSLIRLEN FQKLTELQRD LIGIENLTAP GREFIREGCL YKLTKKGLQQ RMFFLFSDML
LYTSKGVTAT NQFKVHGQLP LHGMIVEESE NEWSVPHCFT IYSAQRTIVV AASSKVEMNK
WIEDLNMAIE MSKKCQEKSD VLLDPSLCDR SNRSSDEVSL EQESEDDMNS SRCSLDKQSH
HRANTTMHVC WHRNTSVSMS DHSLAVENQL SGYLLRKFKN SNGWQKLWVV FTNFCLFFYK
THQDDFPLAS LPLLGYTVST PGESDSIHKE YVFKLQFKSH VYFFRAESEY TFERWMEVIK
SAASATGRMS LLVPKGPAEV NVGN
//
