ID E7FF70_DANRE Unreviewed; 690 AA.
AC E7FF70; A0A8M2B5E4;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Ribosomal protein S6 kinase-like 1 {ECO:0000313|Ensembl:ENSDARP00000128143, ECO:0000313|RefSeq:XP_005159002.1};
GN Name=rps6kl1 {ECO:0000313|Ensembl:ENSDARP00000128143,
GN ECO:0000313|RefSeq:XP_005159002.1,
GN ECO:0000313|ZFIN:ZDB-GENE-111020-10};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000128143};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000128143, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128143};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000128143}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000128143};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005159002.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005159002.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL935141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005159002.1; XM_005158945.4.
DR STRING; 7955.ENSDARP00000128143; -.
DR PaxDb; 7955-ENSDARP00000100510; -.
DR Ensembl; ENSDART00000156806; ENSDARP00000128143; ENSDARG00000079024.
DR Ensembl; ENSDART00000156806.2; ENSDARP00000128143.1; ENSDARG00000079024.5.
DR GeneID; 101886230; -.
DR KEGG; dre:101886230; -.
DR AGR; ZFIN:ZDB-GENE-111020-10; -.
DR CTD; 83694; -.
DR ZFIN; ZDB-GENE-111020-10; rps6kl1.
DR eggNOG; KOG0603; Eukaryota.
DR HOGENOM; CLU_014272_0_0_1; -.
DR OMA; TFRSDWW; -.
DR OrthoDB; 5308056at2759; -.
DR PhylomeDB; E7FF70; -.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000079024; Expressed in retina and 3 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd02677; MIT_SNX15; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR15508; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR15508:SF4; RIBOSOMAL PROTEIN S6 KINASE-LIKE 1; 1.
DR Pfam; PF04212; MIT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00745; MIT; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF116846; MIT domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|RefSeq:XP_005159002.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000313|RefSeq:XP_005159002.1}.
FT DOMAIN 355..679
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 690 AA; 76941 MW; 26009D053EB63D92 CRC64;
MAKKDYLLDA AQQIRMALDR EVNEDYEAAF SYYKNGVDLL LNGVQVDPNK ERREAVKRKT
TQYLKRAEEI FISYLQDNIS KGSTHLGGYS SLRFRSIRHL SSPVENLAMC KVTGVIDKVL
TVESLINKET FIVKSLPKSS WESRERSTII PQGVPFMVKL LKYYVSEDTV FLHLEHLQGG
RLFSRLHRVR SEAIREYPEC FSPNQHKIYL KNSYTLPVLR QNTYLNEDYG RTSPPANHRL
ENCNPRSYCE DVGCQQTGSP SVFASDGLPS VGVPNGLNSL PQDNAPLPIH PCVIVDTRDP
LDVTSDLLGN DVRIERIDSC VDLSKAWGAL EPAQDCRGFT GSNSDILGFR IAAQITPSTL
FGANAQPILC STVNVLPQRV RIIPNASTKH QAHDGFPHEH NSPHRRPSGQ QFVTEFHKVS
SNRYSFECTP QNQDGFTLEF TNITSRGNSG DLGKQDNCQF FSHSFTQPEV SMISCPSAST
TNSACWSETY LEAGHRVNVA GLESKPQINT KNVGAKAKWG RRGLPEDEVR LWGAQILLAL
ESLHEQGIVC QDLNPRNILL RSSGEACLTY FGQWTEVQPE INPKAMEEMY CAPEIGGVSK
VTEACDWWSF GALLYELLTG MPLWQCHPAG VHPHTPLHIP EFLSTAATSL LTELLQFDAC
YRLGSGGGGV SDIKCHPFFS AVPWLKLSSS
//
