ID E7GAL5_9FIRM Unreviewed; 346 AA.
AC E7GAL5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Cobalamin synthesis protein CobW {ECO:0000313|EMBL:EFW04916.1};
GN ORFNames=HMPREF9488_01805 {ECO:0000313|EMBL:EFW04916.1};
OS Coprobacillus cateniformis.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Coprobacillaceae; Coprobacillus.
OX NCBI_TaxID=100884 {ECO:0000313|EMBL:EFW04916.1, ECO:0000313|Proteomes:UP000003157};
RN [1] {ECO:0000313|EMBL:EFW04916.1, ECO:0000313|Proteomes:UP000003157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=29_1 {ECO:0000313|EMBL:EFW04916.1,
RC ECO:0000313|Proteomes:UP000003157};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Sibley C.D.,
RA White A., Strauss J., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA Yandava C., Nusbaum C., Birren B.;
RT "The Genome Sequence of Coprobacillus sp. strain 29_1.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFW04916.1}.
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DR EMBL; ADKX01000032; EFW04916.1; -; Genomic_DNA.
DR RefSeq; WP_008788907.1; NZ_WSNW01000001.1.
DR AlphaFoldDB; E7GAL5; -.
DR STRING; 100884.GCA_000269565_01900; -.
DR GeneID; 78229756; -.
DR eggNOG; COG0523; Bacteria.
DR HOGENOM; CLU_017452_1_3_9; -.
DR OrthoDB; 9808822at2; -.
DR Proteomes; UP000003157; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF62; COBW DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000003157}.
FT DOMAIN 4..178
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT DOMAIN 271..343
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07683"
SQ SEQUENCE 346 AA; 38990 MW; 9B396D9EB2996CE9 CRC64;
MSKVDIISGF LGAGKTTLIK KLIKENLSHE KVVLIENEFG EIGIDGSFLK EAGIEITEMN
SGCICCSLVG DFSEALEKVV KDYHPDRIII EPSGVGKLSD VIQAVINVHD DKLQLNSFIA
VIDAKKCKTY SLNFGEFFNN QIEYASTIIL SRTQDVDQHK LEEDIQIIKT FNTKANIITT
PWDDLTGDTI MNALENKDSL QQVLLKEVEI CPVCGHHHDE EHHHEHECCH EDHHHEHSHE
CECGHHHEHG HHHADEVFTS MGRETIHTYT QDQLETILKT LSSSSQFGSI LRAKGILQTP
EKTWLHFDLV PGEYEVRVGP ADYTGRICVI GKDLLEDKIS ELFGVE
//
