ID   E7GLE8_CLOSY            Unreviewed;       607 AA.
AC   E7GLE8;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Peptidase M24 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF9474_01743 {ECO:0000313|EMBL:EGA94349.1};
OS   [Clostridium] symbiosum WAL-14163.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=742740 {ECO:0000313|EMBL:EGA94349.1, ECO:0000313|Proteomes:UP000002970};
RN   [1] {ECO:0000313|EMBL:EGA94349.1, ECO:0000313|Proteomes:UP000002970}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAL-14163 {ECO:0000313|EMBL:EGA94349.1,
RC   ECO:0000313|Proteomes:UP000002970};
RA   Earl A., Ward D., Feldgarden M., Gevers D., Finegold S.M., Summanen P.H.,
RA   Molitoris D.R., Vaisanen M.L., Daigneault M., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heilman E., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P.,
RA   Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA   White J., Yandava C., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Clostridium symbiosum strain WAL-14163.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGA94349.1}.
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DR   EMBL; ADLQ01000040; EGA94349.1; -; Genomic_DNA.
DR   RefSeq; WP_003510740.1; NZ_GL834308.1.
DR   AlphaFoldDB; E7GLE8; -.
DR   STRING; 1512.GCA_900049235_01900; -.
DR   eggNOG; COG0006; Bacteria.
DR   HOGENOM; CLU_011781_2_4_9; -.
DR   Proteomes; UP000002970; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002970}.
FT   DOMAIN          17..143
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          319..537
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          547..607
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   607 AA;  68493 MW;  BC888A9526E7A4C2 CRC64;
     MEDNKGGTKM EQAVGTRIAA LRKRMAERGM DAYLIPTADF HGSEYVDGYF KARQFITGFT
     GSAGTAVITM EEAGLWTDGR YFVQAAKELA TSEVKLFKMG EEGVPTVEEY LEQTMTMGGV
     LGFDGRVVGG LMGEELQDRL AAKEICIACY EDLIGEIWED RPELPKEPVW ILEDKYAGKP
     ASEKIADLRS TMAEKNAGVH ILTSLDDIIW LLNIRGNDVP CTPVVLSYLI VTRGEILLFI
     NQETLNEEVR TYLAGLGVKL YDYNDIYQVV PSFKNETVML EKAHVNYAVC QSLDNSVTVV
     DMMNPTSSAK AVKNPVEIEN MRKVHIKDGV AMVKFMYWLK QNVGKTEIDE ITAAAYLDKL
     RSEVEGNLGL SFGTISAYSD NAAMCHYAVS EESNKKLMPR GLYLVDSGGQ YLEGTTDITR
     TFALGELTEE EKECFTLVAS CMLRLLNVKF PYGCHGYNFD FAARELLWRR GLDFNHGTGH
     GVSFLGSVHE RPNGVRWRVV PERQDNAVFE EGMITSDEPG LYFEGKFGIR TENLMLCVKA
     EKNEYAQFMK FENLTWVPID LDAIDVKYME PRDRELLNAY HKEVYNKISP YLPEEEAKWL
     EKVTREI
//