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Database: UniProt
Entry: E7MPZ0_9FIRM
LinkDB: E7MPZ0_9FIRM
Original site: E7MPZ0_9FIRM 
ID   E7MPZ0_9FIRM            Unreviewed;       594 AA.
AC   E7MPZ0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN   ECO:0000313|EMBL:EFW23909.1};
GN   ORFNames=HMPREF9430_01716 {ECO:0000313|EMBL:EFW23909.1};
OS   Solobacterium moorei F0204.
OC   Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC   Erysipelotrichaceae; Solobacterium.
OX   NCBI_TaxID=706433 {ECO:0000313|EMBL:EFW23909.1, ECO:0000313|Proteomes:UP000004097};
RN   [1] {ECO:0000313|EMBL:EFW23909.1, ECO:0000313|Proteomes:UP000004097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0204 {ECO:0000313|EMBL:EFW23909.1,
RC   ECO:0000313|Proteomes:UP000004097};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000256|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC       Rule:MF_00203}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFW23909.1}.
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DR   EMBL; AECQ01000031; EFW23909.1; -; Genomic_DNA.
DR   RefSeq; WP_006526520.1; NZ_GL637665.1.
DR   AlphaFoldDB; E7MPZ0; -.
DR   STRING; 706433.HMPREF9430_01716; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OrthoDB; 9804933at2; -.
DR   Proteomes; UP000004097; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR   Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   NCBIfam; TIGR00194; uvrC; 1.
DR   PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR   PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR   SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00203};
KW   Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW   Rule:MF_00203}; Hydrolase {ECO:0000313|EMBL:EFW23909.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004097};
KW   SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT   DOMAIN          15..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000259|PROSITE:PS50164"
FT   DOMAIN          198..233
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   DOMAIN          250..464
FT                   /note="UvrC family homology region profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50165"
SQ   SEQUENCE   594 AA;  68615 MW;  5FDFE62C91B87C21 CRC64;
     MDKEYIKAKL KNLPNEPGSY QMKDKNGEII YVGKAKNLHN RMNQYFVGAH DFKTTKMVSN
     IDDFDFIVTR SEKEALVLEI NLIKKYRPKY NIQFIDDSSY PYIKLTKEKY PRLLIARDTK
     KDKKAKYFGP FPDATAARTT LKLLQSLYPF RRCTHLEPKV CLYYHMHQCI GPCEFDIDPK
     VYDEMSDKVV RFMNGDTKDV EAELQTKMLE ASQALEFEKA QEYKEMLESI RHVVNDKQNI
     EKDNRGSRDV FAWYTKKGYL AITGFLVREG TILNKEFRLR PLYGEAEEEF TSFLVQYYQD
     HPSARELVLP MELDVTALQD VLDMPIFQPQ KGYKVKLLDM CIENAKKQLD LKFNAVARQD
     TLTEQAVAQL CDIAKHPMNR VELFDNSHIS GAFTVASCVV YEDGYPDRKS YRLYKLHTGN
     SDVDSMKEVI YRRYFRMLNE GTRMPDGIIV DGGRTQIDAA KEILDSLDLS DTIKLMGLVK
     DDKHSTNALM DANGDIFDID KDSGLFFLLT RMQDEVHRVA ITYHRKLRAK AQTKSVLDEI
     TGVGPKRKKL LLKEFGNFTN LKAATVEDIA KIIPSEVAQA VYDALHQTYE NTDV
//
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