ID   E7N015_9FIRM            Unreviewed;       548 AA.
AC   E7N015;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE            EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE   AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN   ORFNames=HMPREF9555_00308 {ECO:0000313|EMBL:EFW30679.1};
OS   Selenomonas artemidis F0399.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC   Selenomonas.
OX   NCBI_TaxID=749551 {ECO:0000313|EMBL:EFW30679.1, ECO:0000313|Proteomes:UP000004633};
RN   [1] {ECO:0000313|EMBL:EFW30679.1, ECO:0000313|Proteomes:UP000004633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0399 {ECO:0000313|EMBL:EFW30679.1,
RC   ECO:0000313|Proteomes:UP000004633};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474; EC=3.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000926};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFW30679.1}.
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DR   EMBL; AECV01000001; EFW30679.1; -; Genomic_DNA.
DR   RefSeq; WP_009348966.1; NZ_GL638127.1.
DR   AlphaFoldDB; E7N015; -.
DR   STRING; 749551.HMPREF9555_00308; -.
DR   HOGENOM; CLU_025243_1_0_9; -.
DR   Proteomes; UP000004633; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR   Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR   Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 2.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR001667; DDH_dom.
DR   InterPro; IPR038763; DHH_sf.
DR   InterPro; IPR004097; DHHA2.
DR   InterPro; IPR038222; DHHA2_dom_sf.
DR   InterPro; IPR010766; DRTGG.
DR   InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR   PANTHER; PTHR12112; BNIP - RELATED; 1.
DR   PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01368; DHH; 1.
DR   Pfam; PF02833; DHHA2; 1.
DR   Pfam; PF07085; DRTGG; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01131; DHHA2; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR   SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          75..131
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          254..310
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   548 AA;  60692 MW;  2BB7B7CFADF330E2 CRC64;
     MNVAKPIYVI GHRNPDTDSI CSAIGYAHLK QSLGVNAVAA RAGKINKETK FALEYFHVEQ
     PLLIPDLYPR VKDIAMDCKI VVRQHDTLRH LGEVLRHNDL RSIPVTDSQG ILVGIVSVSD
     LAKRYFQELG MTNLSDMRVR YRDIIHATDS NVLVSGEEGE TIKGQIRIAA GSVHTIKKLV
     KQNDIVLIGD RKEDIVLACI DQGISCLIVT GDGRIPAEAI EEAEKRGIFV LSTPYDTYTV
     ARLINQCVPI RRIMHDNPIC FKPLDLLSDI KGTMEETNFR NYPVLENGRI VGLVSRDRLV
     VSEPVRVILV DHNERNQAVE GIEDAKIVEI IDHHRFGGIS TSEPIYTHAE PVGCTATIVS
     NMHWQNDIDI PPSIAGLLLS AIISDTVLFK SPTCTPADKK AAERLAEIAN VNLNTYGLDM
     LKAGSSVGNM TPMEIVRNDL KEFTIGTYRV IVSQTSVMGT KEIMEKEDEL IAAMKSICES
     EGFDMSLVMI TDILEEATYL LFTGSPRTLI GEAFRKDTSG THLYLPGVMS RKKQIIPPLS
     EAVKRIKS
//