ID E7ND21_9ACTO Unreviewed; 2434 AA.
AC E7ND21;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=MaoC-like protein {ECO:0000313|EMBL:EFW25926.1};
DE Flags: Fragment;
GN ORFNames=HMPREF9057_02703 {ECO:0000313|EMBL:EFW25926.1};
OS Actinomyces sp. oral taxon 171 str. F0337.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=706439 {ECO:0000313|EMBL:EFW25926.1, ECO:0000313|Proteomes:UP000005722};
RN [1] {ECO:0000313|EMBL:EFW25926.1, ECO:0000313|Proteomes:UP000005722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0337 {ECO:0000313|EMBL:EFW25926.1,
RC ECO:0000313|Proteomes:UP000005722};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFW25926.1}.
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DR EMBL; AECW01000501; EFW25926.1; -; Genomic_DNA.
DR eggNOG; COG0304; Bacteria.
DR eggNOG; COG0331; Bacteria.
DR eggNOG; COG2030; Bacteria.
DR eggNOG; COG4981; Bacteria.
DR HOGENOM; CLU_000114_7_0_11; -.
DR Proteomes; UP000005722; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 943..1329
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
FT REGION 1355..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2434
FT /evidence="ECO:0000313|EMBL:EFW25926.1"
SQ SEQUENCE 2434 AA; 255746 MW; C7BCB48C7F861162 CRC64;
MAAAANAGYW AELAGGGQTT PAVLTENLEG LEKALEPGRT AAFNAMFMDR YLWNLHLGTQ
RLLSKARAGG APIDGITISA GIPELEEATA LLERLHAEGF PYIAFKPGTV DQIRQVLAIA
RAVPDSPVII QIEDGHAGGH HSWEDLDTML LATYDAIRAV TNVVLVVGGG IGTPTRAADY
LTGRWAEAYG TAAAPVDGVM IGTAAMTCLE AKTNDDVKQL LVDTPGIPED SGVEGGWVAS
GESIGGMTSG LSHLRADLYE IDNSSARASR LIQELAGDEA AMAARRQEMI DALAKTAKPY
FGDVEEMTYL QWATRHAELC VAPHEGRSAT RADWADEGWY DRFIDLLHRI EARLSQADHG
EIPTLFADYD AVIDSDAALA ALAERYPSAA STLVEPVDAA WFVDLCRKHP KPVPFVPVVD
ADILRWWGTD SLWQSQDPRY TADQVRIIPG PVAVAGITTI NEPIGELLGR FETAAVEALQ
EAGTGEQEAA GRLGAAPAVA DGVLAAPVAD AKELVQVAPH VLWNGHLTVN PATVLDDDAY
NVVARPDVAE DAYDLDIRLD THWDGTPGGD KIHAVRRLVV PLRLARAWDG AAPLVDPERI
SETMNDLLRA TAGVGAVSIT GDDVDHLPEV RPGQAGATDV LGRPTTQPFG TIHGSFTLAS
TLGHDHASVT ADALPADLSA APFVPDALLG PCWPVVYAAL GSVVEDGMPL IEGLLGAVHL
DHTIDLHLTL HQLQEAAATT SPTINVTGWV AALEESSAGR VVDVRLELTD AGDGTVVALM
RERFAIRGRA SGNAVPSAPE LAGGTGRETA PAARRILRRA TVTAPADMTA FARVTGDFNP
IHTSYNAARV AGMEAPLVHG MWLSATAQQV AASTAVDGSR HVLAGWTYVM TGPVELSDDV
EITVERTGLV VGGGYVLEVV CRINGEVVSR GTAVTTPEPT AYVYPGQGIQ APGMGLDEMN
SSKAAREIWE RADAHTRAEL GFSVINLVRD NPTEMTARGV TYRHPEGLLN LTQFTQVALA
TVAMATTARL AEAGALVDGA AFAGHSLGEY TALSAYGRVM PVETTISIVF QRGSTMHSLV
PRDADGASNY RMGALRPNQA GIKADEVEAY VQSISQETGE FLQIVNHNLA GVQYAVAGTI
KGLDALAADA RAKAKARGGK NPFMFVPGID VPFHSEVLRP GVPEFRGRLL ELVPDDLDVE
RLVGHYVPNL VARPFALTQD FARSILEVVP SEPVEEIVAD WDSWVKRPTE LARVLLVELL
AWQFASPVRW IETQEVLLSS PSEGGLGIEH IVEVGLANSP TLANLATNTL RLPQHAGRHV
TVHNARRDEA RVLATDTDPA VELTEPNFDV PAAEEPAAEA AAPAQAATAE QTPAPAAEAS
PVSAAPAAGG PVDDLPFGAT DALTVLLAHA SRIRPEQIGA TDTTETLTNG VSSRRNQLLM
DLGTELELAS IDGAADADMT ALAATVAKGA PGYKAFGPVL TEAIRVGLGR LLGPSGVRAS
RIADRVTGTW GLGQGWVSHV TAALFLGTRE GASMRGEDLA SLGSSAPLTS ASAVDTLIDS
AVQAVAADHG VTVAKPSAGG AGGAVVDSAA LDAFAQSVTG DEGVLATTAR TLLEALGLTE
KATVPADADD EASRTRAALA ALDAELGAGW VTSVTPAFAP ERAVLIDDRW ATAREDVARL
GSGETDLDAS RRLLAPERFV GLGQAVADHA TWWAKQVKDS DLADGAERAA ILTGIAQAAP
KAPQAGDPTV RWSEDVAVVT GVAPGSIAAA VVGELLAGGA TVVATSSRLT HERLEFATTL
YREHAAAGAK LWMVPTNLSS YRDVDALAEW IGNDQVVTSG SSTKVVKEAL VPTLLFPFAA
PRVSGTLADA GPAAESQTRL LLWSVERTIA ALSAIGFDTH VDHRLHVVLP GSPNRGTFGG
DGAYGEVKSA LDAIVNRWSS ERAWAQRVTL AHPRIGWVKG TGLMGGNDPL VAAVEAAGVR
TWTTEEIASE LAGLCTSEVR TRAARTPVNA DLTGGLGDDI DLVALRENAA AQAAAPTEET
EAPAVIKALP TPVMPTQPTA PQWGEVSADP DDLVVIISTG EVSTWGSGRT RREAELGMSG
GEDVDLTAAG VLELAWGMGL LTWQDSPKAG WYDTDGEMVE ESDILERYRD EVVARCGIRE
FVDDGVIAPI ADEEVTVYLD RDITLSVPDE ATARTIEASD PEHTLVVPDA ETGEWTVTRL
AGSLARVPRR AALSRTVGGQ FPRDFDPERW GIPASMTQGM DPIASWNLVT AVDAFLSAGF
TPAELLKAVH PSDVASTQGT GFGGMESMRK MFVGRFLGEE RPSDILQEAL PNVVAAHVMQ
SYIGGYGAMV QPVSACATAA VSIEEGWDKI ALGKADVVVA GAIDDISIES VVGFGNMNAT
AEAAAMRAKG ISDRHFSRAN DRRRGGFVEA EGGG
//
