ID   E7NQK3_TREPH            Unreviewed;       417 AA.
AC   E7NQK3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Transporter, major facilitator family protein {ECO:0000313|EMBL:EFW39149.1};
GN   ORFNames=HMPREF9554_00333 {ECO:0000313|EMBL:EFW39149.1};
OS   Treponema phagedenis F0421.
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=754027 {ECO:0000313|EMBL:EFW39149.1, ECO:0000313|Proteomes:UP000004157};
RN   [1] {ECO:0000313|EMBL:EFW39149.1, ECO:0000313|Proteomes:UP000004157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0421 {ECO:0000313|EMBL:EFW39149.1,
RC   ECO:0000313|Proteomes:UP000004157};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFW39149.1}.
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DR   EMBL; AEFH01000029; EFW39149.1; -; Genomic_DNA.
DR   RefSeq; WP_002695472.1; NZ_GL637980.1.
DR   AlphaFoldDB; E7NQK3; -.
DR   STRING; 162.TPHV1_390010; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_034180_16_0_12; -.
DR   Proteomes; UP000004157; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06173; MFS_MefA_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR010290; TM_effector.
DR   PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR   PANTHER; PTHR23513:SF6; MULTIDRUG EFFLUX PUMP TAP; 1.
DR   Pfam; PF05977; MFS_3; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        78..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        264..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        288..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        312..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        349..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          222..417
FT                   /note="Major facilitator superfamily (MFS) profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
SQ   SEQUENCE   417 AA;  46553 MW;  43115E696AD77435 CRC64;
     MKNKINYQIN RDAVKFILSQ GISVLGSSVV NFSIIWYLVL KTSSSYILTI TILCTYIPQA
     LIALGLSHIG DRYNKKVLII IGDIITAFVT LLLYIMISKG YDSLKYIYIT CVLRSFGAGI
     QLPMVNSFLP NICDNSELKK VNSLNSTVNS LIQLVSPGIG GVILATFGFK GSLLIDVLTA
     IISILILSKI KYKILQENNT GDKIFNARDI YDVWKHIKKS TILNRLIVFC VLFNFFVSIP
     AFFTPILVSQ VYVGSIMKLT LNETMWSVGT LVGGVLLFFA KNNTIKKYAV TIKEAVIVFG
     LSIFLLGVVS NFILYLIILF VSGVAMTLYS TLNNIIIQSI TSERYIGRVF SVIQTIISVA
     TPFGIIILGM LSEYMGIRFV MSLSGIFIII GVLFSKYWEE TRKYILLKEM LSIYMSA
//