ID E7NS99_TREPH Unreviewed; 768 AA.
AC E7NS99;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Putative DnaQ family exonuclease/DinG family helicase {ECO:0000313|EMBL:EFW38562.1};
GN ORFNames=HMPREF9554_00938 {ECO:0000313|EMBL:EFW38562.1};
OS Treponema phagedenis F0421.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=754027 {ECO:0000313|EMBL:EFW38562.1, ECO:0000313|Proteomes:UP000004157};
RN [1] {ECO:0000313|EMBL:EFW38562.1, ECO:0000313|Proteomes:UP000004157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0421 {ECO:0000313|EMBL:EFW38562.1,
RC ECO:0000313|Proteomes:UP000004157};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. DinG subfamily.
CC {ECO:0000256|ARBA:ARBA00038058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFW38562.1}.
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DR EMBL; AEFH01000081; EFW38562.1; -; Genomic_DNA.
DR RefSeq; WP_002696875.1; NZ_GL638025.1.
DR AlphaFoldDB; E7NS99; -.
DR STRING; 162.TPHV1_130059; -.
DR eggNOG; COG1199; Bacteria.
DR HOGENOM; CLU_012117_2_0_12; -.
DR Proteomes; UP000004157; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF47; FANCONI ANEMIA GROUP J PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Exonuclease {ECO:0000313|EMBL:EFW38562.1};
KW Helicase {ECO:0000313|EMBL:EFW38562.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000313|EMBL:EFW38562.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 92..384
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 86989 MW; 75A0BABCFAF94424 CRC64;
MKNSAKLFGK HFDPSDTEEN SFDDFSDDGY RDADNFGELN DFSDEAYHDS VNDYDVESSE
IFYDTESDED SEPVIIPLYT AQIVEYLDET GSFASFFERY EVRHAQLDLT EEIANCFNND
SIGVFEAGTG VGKSLAYLIP AIKWALQNKE RVVISTGTIN LQQQLMEKDL PSAKKIIGKE
AKDLKVLLLK GRHNYLCIRR LMQALQEPDL FNDDYDEIKK IQAWAATSAD GSKAEMPFVP
SDKVWAKVCA ESDNCLGRRC PYYADSFVMK LKKEAAKASL LIVNHHLLFA DLAARYEGYG
YQTTAVLPPF KRLIFDEAHT MEDAAQSFFS KTFSQFELQR QINALYRHKK GKPIGVLPKL
ITIAHADEIV PEITKTLFEL QTAYAVLDSE ALPLCSSGAI SFQQMLPYQR DALTQKLSAV
RRNLEIVIHH FTAVIDTVSD DEQSEDTVQD AKLILWRFRE LKETAESFEQ WKKLSEKVFW
IEKIRSAQKE TVRFHQTPLN LASLLHDAVF FPMRTVICLS ATLKIGESFD YWLNRTGLNL
PIDAPLITKT FPSPFPYKRN VLLNVPIDAP PPDDKEFQNW INKAIAEMIE LSGGKTLVLF
TSYESLKTAC AHARAALKDT DLLILQQGED DRSRLLNFFK ENVSSSLFAT TSFWAGIDVP
GESLTHVILV KLPFSVPTDP VFKAKADAID SAGGSSFMSL SVPEAVIQFR QGFGRLMRSQ
SDRGIVTLLD KRVIAKRYGQ IFITSLPETR QCFDSFKNIL YNIENFLF
//
