ID E7NSI0_TREPH Unreviewed; 667 AA.
AC E7NSI0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=HAMP domain protein {ECO:0000313|EMBL:EFW38475.1};
GN ORFNames=HMPREF9554_01019 {ECO:0000313|EMBL:EFW38475.1};
OS Treponema phagedenis F0421.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=754027 {ECO:0000313|EMBL:EFW38475.1, ECO:0000313|Proteomes:UP000004157};
RN [1] {ECO:0000313|EMBL:EFW38475.1, ECO:0000313|Proteomes:UP000004157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0421 {ECO:0000313|EMBL:EFW38475.1,
RC ECO:0000313|Proteomes:UP000004157};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000256|ARBA:ARBA00029447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFW38475.1}.
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DR EMBL; AEFH01000086; EFW38475.1; -; Genomic_DNA.
DR AlphaFoldDB; E7NSI0; -.
DR STRING; 162.TPHV1_170063; -.
DR eggNOG; COG0840; Bacteria.
DR HOGENOM; CLU_000445_107_19_12; -.
DR Proteomes; UP000004157; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd12914; PDC1_DGC_like; 1.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR InterPro; IPR029151; Sensor-like_sf.
DR PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00304; HAMP; 2.
DR SMART; SM00283; MA; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 2.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW ProRule:PRU00284};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 280..334
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 381..610
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000259|PROSITE:PS50111"
FT COILED 417..444
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 667 AA; 72332 MW; B44437142CD1EF8F CRC64;
MRISQKAVIE KVEAHLIDKA NDTAEIINGR IQAFFQFLEG IARTPVFADT ALSYQEKVKL
LKDEAAWHSN ILLISIADSA GDLHTYGEKM VNVRDQEWFS AGMQGKSFVS EPFVSALNGQ
LIIVIATPLY DKEHRIIGVL NVTMNGLWLW DNIKDIKVGK TGECYILGPT GVTLADEDPD
LIRNHENSIE AAKTDSALKN IAALETQAIE SIEPSIGFYK WRGKERIAAF AKIKSTGWTV
IVYAPINDFL GSIQSLKISL YLVGSSILLI AFAIIFFMAR TIVKPIVVTV NVLRNIAKGD
GDLTARLPVV GNDEITDLAD YFNQTIEKIG ETVKQVTENT QIMQDIGVEL SSNMTETASS
VHQINVHIDG VKQQVLTQAA SVTETAATIE EILRTIKQLD TSIENQATSV VQSSSAIEEM
VANIDSITQT LEKANAAIKE LASATSEGKD SIITSSNVTQ DISEESGILL EASNVIQHIA
SQTNLLAMNA AIEAAHAGDA GKGFAVVADE IRKLAEESSM QGKNITATLK TLSSEIDILS
ASSQTVEEKF NAIFGLSGQV KDMSNHLMEA MREQEHGSTE VLAAIKDINN VTAQVKEGSA
EMLLGGESVA KEMQKLDSLT RVITGSMNEM ASGAMQINEA IQEVAAITEK NKKSIENLSV
EVSKFKI
//
