ID E7NTG0_TREPH Unreviewed; 687 AA.
AC E7NTG0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=7TM diverse intracellular signaling {ECO:0000313|EMBL:EFW38164.1};
GN ORFNames=HMPREF9554_01352 {ECO:0000313|EMBL:EFW38164.1};
OS Treponema phagedenis F0421.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=754027 {ECO:0000313|EMBL:EFW38164.1, ECO:0000313|Proteomes:UP000004157};
RN [1] {ECO:0000313|EMBL:EFW38164.1, ECO:0000313|Proteomes:UP000004157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0421 {ECO:0000313|EMBL:EFW38164.1,
RC ECO:0000313|Proteomes:UP000004157};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFW38164.1}.
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DR EMBL; AEFH01000109; EFW38164.1; -; Genomic_DNA.
DR RefSeq; WP_002697809.1; NZ_GL638042.1.
DR AlphaFoldDB; E7NTG0; -.
DR STRING; 162.TPHV1_260028; -.
DR eggNOG; COG2114; Bacteria.
DR HOGENOM; CLU_000445_105_5_12; -.
DR Proteomes; UP000004157; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..578
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 687 AA; 77276 MW; 193405323B21D0DC CRC64;
MNSDIKKIIL GAIPFYLLLI ALYIIYLGTP ISKRNIVDVT VEKGTAFIPG DRAALFSLRG
EFTFTPNCFS VLKNPDRETY GKIPGTFLHT EMNSKFGYGS YGLEISGLDP DVIYAMQVAH
ALSSCSIIIN GKEADSQGKP GIDKATELPG TKFSETVFRP LPDGTATMIF NVSNFRNTKG
GITGAIILGE SSKLAERIRG DFIFAGCIFA VTFSVAIFFF LLSFFYKQSS FIIWFALASM
SLALRGIFFY PHIVPTFFPN LSWYANFILR YVTVPLPVIL FTVFIRKALK LCYKIPYVLI
LSVSIVYAVS TLVLPPEISS QILIYYQIFM IFGVLYTIYI TVIGLIKKKE FSGWIFSAII
ILFLFGIYDL LVALKIIPGR FLIHVASIFP VLLLSVMVLN DYAGSIKKIQ DLTEEMQLIN
KSLVRFVPEQ IITLLQKKSI RDVKLGDNVE LTMPILSIDI RSFTHTSEKL SPNQVFDLLN
RYFTFVSPIV REYNGIITKY LGDGFFALFP DGVDAALAAG IKIQKALQSK NIMLPNTQPL
RIGVGIDMGN ILLGTIGDTT RMDSIIISNA YYIAEILQES TKKYSSRIII SDRIFASLTD
PTQYFIRPVE KIKTISNKEN FLFEVYDCDE KTIRDLKYHS QGYIEHAIQA LSDKGAAAAR
KYIDEALKIY PNDHVALYYK KEFLKQV
//
