ID   E7NVF0_TREPH            Unreviewed;       254 AA.
AC   E7NVF0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=RNA methyltransferase, TrmH family {ECO:0000313|EMBL:EFW37482.1};
GN   ORFNames=HMPREF9554_02057 {ECO:0000313|EMBL:EFW37482.1};
OS   Treponema phagedenis F0421.
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=754027 {ECO:0000313|EMBL:EFW37482.1, ECO:0000313|Proteomes:UP000004157};
RN   [1] {ECO:0000313|EMBL:EFW37482.1, ECO:0000313|Proteomes:UP000004157}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0421 {ECO:0000313|EMBL:EFW37482.1,
RC   ECO:0000313|Proteomes:UP000004157};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFW37482.1}.
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DR   EMBL; AEFH01000176; EFW37482.1; -; Genomic_DNA.
DR   RefSeq; WP_002699366.1; NZ_GL638082.1.
DR   AlphaFoldDB; E7NVF0; -.
DR   STRING; 162.TPHV1_150048; -.
DR   GeneID; 57754087; -.
DR   eggNOG; COG0566; Bacteria.
DR   HOGENOM; CLU_021322_2_0_12; -.
DR   Proteomes; UP000004157; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd18095; SpoU-like_rRNA-MTase; 1.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR   PANTHER; PTHR46429:SF2; TRNA_RRNA METHYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
DR   SUPFAM; SSF55315; L30e-like; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:EFW37482.1};
KW   Transferase {ECO:0000313|EMBL:EFW37482.1}.
FT   DOMAIN          10..85
FT                   /note="RNA 2-O ribose methyltransferase substrate binding"
FT                   /evidence="ECO:0000259|SMART:SM00967"
SQ   SEQUENCE   254 AA;  27899 MW;  61B7B2DE737B70FB CRC64;
     MGTQHRKELP VCGFEAVKAL VKQHPEKISR LFFTQERAKA FGDASKYLAA KKRLYRVVEE
     ADLEKLSLSV HHQGVVAMIE EPVIPLIDEQ IIDGWAKDSA VVLFLDRVGN SNNLGAIIRS
     AAFFGIPAVI ITDEDPQAKI TTSAYRVAQG GMEFVTIYHT RSIQWLLRAC EGKITRIGAD
     HRSFRNLNSL PTLLSPDEAT MIILGNEETG LSEASKKACD HLVKIPGSGA IESLNVAQAG
     TLFLAALADI HRQR
//