ID E7RXN1_9BURK Unreviewed; 246 AA.
AC E7RXN1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Heme exporter protein C {ECO:0000256|ARBA:ARBA00016463, ECO:0000256|RuleBase:RU364092};
DE AltName: Full=Cytochrome c-type biogenesis protein {ECO:0000256|RuleBase:RU364092};
GN Name=ccmC {ECO:0000256|RuleBase:RU364092,
GN ECO:0000313|EMBL:EFV94705.1};
GN ORFNames=HMPREF0551_1452 {ECO:0000313|EMBL:EFV94705.1};
OS Lautropia mirabilis ATCC 51599.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Lautropia.
OX NCBI_TaxID=887898 {ECO:0000313|EMBL:EFV94705.1, ECO:0000313|Proteomes:UP000011021};
RN [1] {ECO:0000313|EMBL:EFV94705.1, ECO:0000313|Proteomes:UP000011021}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51599 {ECO:0000313|EMBL:EFV94705.1,
RC ECO:0000313|Proteomes:UP000011021};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the export of heme to the periplasm for the
CC biogenesis of c-type cytochromes. {ECO:0000256|ARBA:ARBA00002442,
CC ECO:0000256|RuleBase:RU364092}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU364092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family.
CC {ECO:0000256|ARBA:ARBA00005840, ECO:0000256|RuleBase:RU364092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFV94705.1}.
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DR EMBL; AEQP01000010; EFV94705.1; -; Genomic_DNA.
DR RefSeq; WP_005673729.1; NZ_GL636062.1.
DR AlphaFoldDB; E7RXN1; -.
DR STRING; 887898.HMPREF0551_1452; -.
DR eggNOG; COG0755; Bacteria.
DR HOGENOM; CLU_066538_2_0_4; -.
DR Proteomes; UP000011021; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR NCBIfam; TIGR01191; ccmC; 1.
DR PANTHER; PTHR30071:SF17; CYTOCHROME C ASSEMBLY PROTEIN-RELATED; 1.
DR PANTHER; PTHR30071; HEME EXPORTER PROTEIN C; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01386; CCMCBIOGNSIS.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364092};
KW Cell membrane {ECO:0000256|RuleBase:RU364092};
KW Cytochrome c-type biogenesis {ECO:0000256|RuleBase:RU364092};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364092};
KW Reference proteome {ECO:0000313|Proteomes:UP000011021};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364092}; Transport {ECO:0000256|RuleBase:RU364092}.
FT TRANSMEM 12..39
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364092"
FT TRANSMEM 51..78
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364092"
FT TRANSMEM 90..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364092"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364092"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364092"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364092"
FT DOMAIN 6..182
FT /note="Cytochrome c assembly protein"
FT /evidence="ECO:0000259|Pfam:PF01578"
SQ SEQUENCE 246 AA; 27607 MW; 148BEBE83FFEBC62 CRC64;
MNLFAYAAPQ RFYALAGRLI PWFAVSAALL CLVGLWLGFW EAPTDFQQGE VYRIIFIHVP
AAWMAMFIYL VMAIYAILNL GFRTRMSAMM IAALAPTGAL WAAIALWTGS LWGKPTWGTY
WAWDARMTST LILLFLYFGY LALTNAIEDR NRADRAGSIL VLVGSINVPI IYFSVNLWNT
LHQGSSVNPV SGSKMATVML LAMLVMSLAA WCYSVAVVLH RARSIILVRE AHTQWVHELQ
EHPEKS
//
