ID E8LHX8_SUCHY Unreviewed; 849 AA.
AC E8LHX8;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895,
GN ECO:0000313|EMBL:EFY07874.1};
GN ORFNames=HMPREF9444_00291 {ECO:0000313|EMBL:EFY07874.1};
OS Succinatimonas hippei (strain DSM 22608 / JCM 16073 / KCTC 15190 / YIT
OS 12066).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Succinivibrionaceae; Succinatimonas.
OX NCBI_TaxID=762983 {ECO:0000313|EMBL:EFY07874.1, ECO:0000313|Proteomes:UP000018458};
RN [1] {ECO:0000313|EMBL:EFY07874.1, ECO:0000313|Proteomes:UP000018458}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22608 / JCM 16073 / KCTC 15190 / YIT 12066
RC {ECO:0000313|Proteomes:UP000018458};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFY07874.1}.
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DR EMBL; AEVO01000011; EFY07874.1; -; Genomic_DNA.
DR RefSeq; WP_009142516.1; NZ_GL830949.1.
DR AlphaFoldDB; E8LHX8; -.
DR STRING; 762983.HMPREF9444_00291; -.
DR GeneID; 78338879; -.
DR eggNOG; COG0557; Bacteria.
DR HOGENOM; CLU_002333_7_3_6; -.
DR OrthoDB; 9764149at2; -.
DR Proteomes; UP000018458; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000018458};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 655..734
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 794..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..849
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 96128 MW; 4681AEBC9889C107 CRC64;
MQEVYDRILK DKNAPQGTAQ SNLKCALYLV LCLYKINFND VKSLSLMSYL LSSVGYKGSL
LNITKDQYEA LAAELVNEGS LVLIGDYSAY SRPGALKEFV AKIRAKKLNT SGTDDFVYYI
EDDKGREFSL VTKFALLPGD EAKVKANYDS GKAYVFELVT KRAAVIGRIQ QLKKNHIELI
PDEPNLGFIR FVFESPEAVG EALPGDIVIA EITKRQVFSC LIKTRKVVKD LGSLNDKIIR
AILKHDIPNS WPDNLIRSLS RVPSVVKQDE LKGRVDVRDL PLVTIDGEDA RDFDDAVYAR
QEEKGWTLYV AIADVSYYVK PGTLLDKEAL LRCNSVYFPN YVVPMLPEKL SNGICSLNPN
VDRMCMVCEL SIDNSGKTKK YSFYPAVMRS HARLTYTEAW RMISEQSCEF EEHKPYIHDL
SVLHDLYKAL RKARDNRGAI NIESEEVKFI FNENLEISGI SPVVRNDAHM LIEECMIAAN
VAAAEFVSSR KSHTLYRIHA KPTEKKLTAL KAYLSRIGLE LPGGDDPSSM DYARFVKQIE
KREDNKIIGE LLLRSLSKAE YSPDNIGHFG LALEKYAHFT SPIRRYPDLQ LHRVIKHLLE
KEKKRDWGKI GARAYTKEEL QVLGTRCSER EVEAFYAEMD VDADLKCEYL KQFIGQTLDG
TITACTKFGI FVRLNDFYID GMIHIASFDE FMTFNERSQT LRGGTGRVFA VGDKIKAILA
GINTDEHKIE LFPDTNENRI MIRSTAGKKK TKSKKSQVKA KVINTAVDKD AFFKSIADIT
RNQTATAEDA VLREEEQPKK NLPVAEEFGD EVLFTESSEH KKHGKRHKKK AKSQKNATGS
KNGKKKRKK
//
