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Database: UniProt
Entry: E8LM92_SUCHY
LinkDB: E8LM92_SUCHY
Original site: E8LM92_SUCHY 
ID   E8LM92_SUCHY            Unreviewed;       369 AA.
AC   E8LM92;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   08-MAY-2019, entry version 41.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=HMPREF9444_01877 {ECO:0000313|EMBL:EFY06364.1};
OS   Succinatimonas hippei (strain DSM 22608 / JCM 16073 / KCTC 15190 / YIT
OS   12066).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Succinivibrionaceae; Succinatimonas.
OX   NCBI_TaxID=762983 {ECO:0000313|EMBL:EFY06364.1, ECO:0000313|Proteomes:UP000018458};
RN   [1] {ECO:0000313|EMBL:EFY06364.1, ECO:0000313|Proteomes:UP000018458}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22608 / JCM 16073 / KCTC 15190 / YIT 12066
RC   {ECO:0000313|Proteomes:UP000018458};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B.,
RA   Courtney L., Fronick C., Harrison M., Strong C., Farmer C.,
RA   Delahaunty K., Markovic C., Hall O., Minx P., Tomlinson C.,
RA   Mitreva M., Hou S., Chen J., Wollam A., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Zhang X., Suruliraj S., Warren W., Chinwalla A.,
RA   Mardis E.R., Wilson R.K.;
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFY06364.1}.
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DR   EMBL; AEVO01000131; EFY06364.1; -; Genomic_DNA.
DR   STRING; 762983.HMPREF9444_01877; -.
DR   EnsemblBacteria; EFY06364; EFY06364; HMPREF9444_01877.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   BioCyc; GCF_000188195-HMP:HMPREF9444_RS08610-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000018458; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018458};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018458};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:EFY06364.1}.
FT   DOMAIN       58    352       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   369 AA;  40957 MW;  53BF4E6009720764 CRC64;
     MNLKNSRMIP QAPNSRQGIV DSRLSDIYQL LPPVALVEKF PATDFTDNLV KGTRKIFHDI
     LCDSDDRLVV IAGPCSIHDP KAALDYAARL LELRKRYADQ LEIIMRVYFE KPRTTIGWKG
     LINDPDLDGS YDINNGLRIA RKLLRDLNEM GIPAATEYLD TISPQYIDEF ISWGAIGART
     TESQVHRELA SGLSCPVGFK NATNGSVKIA MDAVIAAKHE HTFMSVTKFG YVAIVHTKGN
     EDCHIILRGG KEPNYKKADV DAACDMLVKA GLRPKVMIDF SHSNSLKQFK KQIDVGNDVA
     AQIAAGDNRI FGVMIESNLV EGNQPLSRNL DELEYGKSIT DACVGFDDTV KIIETLNNAV
     LERRKVHQA
//
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