ID E8N2N0_ANATU Unreviewed; 686 AA.
AC E8N2N0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN OrderedLocusNames=ANT_08020 {ECO:0000313|EMBL:BAJ62836.1};
OS Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 /
OS UNI-1).
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Anaerolinea.
OX NCBI_TaxID=926569 {ECO:0000313|EMBL:BAJ62836.1, ECO:0000313|Proteomes:UP000008922};
RN [1] {ECO:0000313|EMBL:BAJ62836.1, ECO:0000313|Proteomes:UP000008922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1
RC {ECO:0000313|Proteomes:UP000008922};
RA Narita-Yamada S., Kishi E., Watanabe Y., Takasaki K., Ankai A., Oguchi A.,
RA Fukui S., Takahashi M., Yashiro I., Hosoyama A., Sekiguchi Y., Hanada S.,
RA Fujita N.;
RT "Whole genome sequence of Anaerolinea thermophila UNI-1.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 42 family.
CC {ECO:0000256|ARBA:ARBA00005940}.
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DR EMBL; AP012029; BAJ62836.1; -; Genomic_DNA.
DR RefSeq; WP_013559228.1; NC_014960.1.
DR AlphaFoldDB; E8N2N0; -.
DR STRING; 926569.ANT_08020; -.
DR GeneID; 78349262; -.
DR KEGG; atm:ANT_08020; -.
DR eggNOG; COG1874; Bacteria.
DR HOGENOM; CLU_400987_0_0_0; -.
DR InParanoid; E8N2N0; -.
DR OrthoDB; 9800974at2; -.
DR Proteomes; UP000008922; Chromosome.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd03143; A4_beta-galactosidase_middle_domain; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR013738; Beta_galactosidase_Trimer.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR003476; Glyco_hydro_42.
DR InterPro; IPR013529; Glyco_hydro_42_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR36447; BETA-GALACTOSIDASE GANA; 1.
DR PANTHER; PTHR36447:SF2; BETA-GALACTOSIDASE YESZ; 1.
DR Pfam; PF02449; Glyco_hydro_42; 2.
DR Pfam; PF08532; Glyco_hydro_42M; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008922}.
FT DOMAIN 25..98
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 107..329
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 381..587
FT /note="Beta-galactosidase trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08532"
SQ SEQUENCE 686 AA; 77414 MW; AFCFC3FE6AE77216 CRC64;
MSMIEPSTRF PFGVVLYREP APSPNELQRD IQILRQQGIR LVGFPVNWAI LQPAQGDWQW
DVYESWLEHA RQLGMEILPV FQSQHVPAWV SHPAYHPESF EAWLGFVRGV VERWGAWTEV
AVWGVDWSGV THDTSSLLQS FAQWLEDHFG SLSTLNGRWK TAFSHWEDIQ PEKWRPEDVP
QQVAWHAFLE DLQTEQMNHL VKEIRLADPR GRAVGSFLLE GKGREVPADF PGVSCFPTRQ
AVHPWDDAAA HPEKHIRQKE TVLARMLSVA FVGDHSRRLG ENEQGFWLAP LQAGAEQTLW
QAEEPLSPEE LRRWVLTALS TGAAGVLFSG VRPGMNPYGR GFSLLESEGE SSPRLREAAL
LAKALEPYAD LFTQGHLADV QVGIVLDDLN RRVCESLPGM GEHYHYSVRG WHRLLWEEGF
PMDFVPASLV DESLAERYRA LVLPFPLALE DETARRLSAY VSAGGNLVSE VGAGMLNEDG
WAVSGEFSPL LRYLFGVRVV NQRLIGEPEE SPRWSIAGKR QGGADEPGYL EGRGPMEGLR
VRANWLIQQY ENQGSQPVFW YRGRPAGSFR VGVRGQAWLI GTVVGHSAFA HVELESRLFV
HRLMEWFGVH PQRIGNVLVR SRVSGNREAW FLTNPTAETV TAQISLPGQW GEDLLGLPLE
WREGKALLTL KPFEVRVILA NSDKQM
//
