ID E8N9M7_MICTS Unreviewed; 926 AA.
AC E8N9M7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=DNA segregation ATPase FtsK/SpoIIIE {ECO:0000313|EMBL:BAJ73274.1};
GN Name=ftsK {ECO:0000313|EMBL:BAJ73274.1};
GN OrderedLocusNames=MTES_0310 {ECO:0000313|EMBL:BAJ73274.1};
OS Microbacterium testaceum (strain StLB037).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=979556 {ECO:0000313|EMBL:BAJ73274.1, ECO:0000313|Proteomes:UP000008975};
RN [1] {ECO:0000313|EMBL:BAJ73274.1, ECO:0000313|Proteomes:UP000008975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=StLB037 {ECO:0000313|EMBL:BAJ73274.1,
RC ECO:0000313|Proteomes:UP000008975};
RX PubMed=21357489; DOI=10.1128/JB.00180-11;
RA Morohoshi T., Wang W.-Z., Someya N., Ikeda T.;
RT "Genome sequence of Microbacterium testaceum StLB037, an N-acylhomoserine
RT lactone-degrading bacterium isolated from potato leaves.";
RL J. Bacteriol. 193:2072-2073(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=StLB037;
RA Morohoshi T., Wang W.Z., Someya N., Ikeda T.;
RT "Genome sequence of Microbacterium testaceum StLB037.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination.
CC {ECO:0000256|ARBA:ARBA00024986}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
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DR EMBL; AP012052; BAJ73274.1; -; Genomic_DNA.
DR AlphaFoldDB; E8N9M7; -.
DR STRING; 979556.MTES_0310; -.
DR KEGG; mts:MTES_0310; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_2_1_11; -.
DR Proteomes; UP000008975; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 532..732
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 549..556
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 926 AA; 98092 MW; 5099518B5AC820D3 CRC64;
MKPASVRTNV GGPAYRGTMA RTSSPSGGRA PAKGTPRPKA AAPAPKRSAP APKRYVDEPE
KPSIAVRAWM AVAHGVGGMF RAFGLESLER DQRRDGFPFF LVVLAVVGAV VEWFFIGNDV
AAVISAYSFG ALVGRVAFVL PVLLLLLAGW LFRHPASVHD NGRVGIGWAL FIITVAGFCH
VAGDRPVPSN GGLPVLSLSG GLAGWIVGEP LALLLTNVGA YIALSLLAVL SILILTKTPP
NRIGRRLGDL YAWMFGVERI EPSDTTTKVL PAAEDDDEPA EKSLPWWRRN KSGREEDVDG
SLGSDDLTEL LTPGTPQGGF ESPVVAPEQI TAPVRPLSPP PPAPDALTEV FDAATLAKAA
SGRGLHDDSP VDDVPDDDMP GISGLGGDNA GAPPSANYRL PAVTALATGT PPKARSAAND
AVVKAIESVM EQFKVDARVT GFSRGPTVTQ YEIEVGPGVK VERITALTNN IAYAVASNEV
RILAPIPGKS AIGVEIPNAD REIVTLGDIL RSDAATSSTH PMTIGVGKDV GGGFVVANLA
KMPHLLVAGS TGSGKSSFVN SMITSLLMRA KPSDVRMVLI DPKRVELTSY AGVPHLITPI
ITNPKKAAEA LQWVVKEMDM RYDDLASFGF RHIDDFNKAV VAGEIKLPPG SERVLKPYPY
LLVVVDELAD LMMVAPRDVE DSIVRITQLA RASGIHLVLA TQRPSVDVVT GLIKANVPSR
LAFAVTSVTD SRVILDQPGA DRLIGQGDGL FLPMGASKAV RVQGAWVSEQ EIEKVVAHVT
QQARPEYRSD VQAAAEKKEI DADIGDDLEL LLAAAELVVS TQFGSTSMLQ RKLRVGFAKA
GRLMDLLESR EIVGPSEGSK ARDVLVTNEQ LPTVLAKLRG DDVPAAAAAD DDRYGADPIE
AQFEGVPVVD DDDEGSEDAW QLTGRD
//
