ID E8QXV1_ISOPI Unreviewed; 926 AA.
AC E8QXV1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Peptidase M16 domain protein {ECO:0000313|EMBL:ADV60930.1};
GN OrderedLocusNames=Isop_0335 {ECO:0000313|EMBL:ADV60930.1};
OS Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B).
OC Bacteria; Planctomycetota; Planctomycetia; Isosphaerales; Isosphaeraceae;
OC Isosphaera.
OX NCBI_TaxID=575540 {ECO:0000313|EMBL:ADV60930.1, ECO:0000313|Proteomes:UP000008631};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43644;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders E., Brettin T.,
RA Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Eisen J.A.;
RT "The complete sequence of chromosome of Isophaera pallida ATCC 43644.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV60930.1, ECO:0000313|Proteomes:UP000008631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43644 / DSM 9630 / IS1B
RC {ECO:0000313|Proteomes:UP000008631};
RX PubMed=21475588; DOI=10.4056/sigs.1533840;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Goker M., Cleland D., Saunders E., Lapidus A., Nolan M., Lucas S.,
RA Hammon N., Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Detter J.C., Beck B., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Isosphaera pallida type strain (IS1B).";
RL Stand. Genomic Sci. 4:63-71(2011).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002353; ADV60930.1; -; Genomic_DNA.
DR RefSeq; WP_013563219.1; NC_014962.1.
DR AlphaFoldDB; E8QXV1; -.
DR STRING; 575540.Isop_0335; -.
DR KEGG; ipa:Isop_0335; -.
DR eggNOG; COG0612; Bacteria.
DR HOGENOM; CLU_007487_1_0_0; -.
DR InParanoid; E8QXV1; -.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000008631; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008631};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 793..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..141
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 177..355
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 662..836
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 926 AA; 103806 MW; 7391E0CDCA5FF487 CRC64;
MSSSPLYSPR TERLANGLTV ITQHDPWAAV AAVQLWFHVG SKNDPPGREG FAHMLEHIMF
NGSDRIGYAD HLKEVFKAGG LDCNAYTTYD QTVYHALIPP EQLDLVLWLE AERLAFLKVD
QKALDHERRR IEVERTITGS DPLTRQCLKY HSLQFETHPY RNAPIGQFAH LRSTAVAELR
EFWEDYYVPN NATLVVVGPL THEEVMTTAR KNLEWIPARG VPPQSSVVEP LPTKPRKHTF
TDNEVPLPLV LLSWPTVPSG HTDEPALRLL ARVIDKAIRE TLNKPRQFLG IKLNDIPQAI
FTKCDAFFLE EAGCFQILAM RPHFQFSADQ LINCIQKIVD RVRQAPADAD HFTKAHDLLR
WDLAIDSCNP HGRALMLGWC GVIQGNPESS NHLWHAIQTL TAADVHQCAQ TYLIPQRRLV
ASYRQSFWGK WFRKSDDKDQ PVIAPMEDVP AAPERPGAVR PENHPEKPPL APIFAAPRVT
TQVERHVLSN GLTVQLLPEP GYPTIRARLT QMVDPRNGFP RGTIGFPRGT IDRVQEILLD
QSGWAFNSKR QQRNDPLPPI ESQIIKKHDC DYGMIAIDTL ADHLDAAIDC LANLINRAER
EGFQKTAVQD ARARAGVQRA TNPGDVEGNA TVRLLERTLL GPRHPYTPDP RAKDDAQAHD
RLNPQELQTW WQRHGRPGSA SLTISGGFNP TATLERVQTQ FRFWRGCDSK NVNLFANPSL
VEPTSTRILL RQGPKNGAAW VAVGRPGLPV DHPDVPKSLA INEYLIHIPN DRLTHTLRYQ
RDISMGGGGG FRFWRGAGLF MLFTICPAAA AADAVLALFD EIRRLRVEPP NEEEWTWTRA
RLVSNLLSNI AGPHERGDGI ALAQARGLRS DFLEQHMSCL SSMTPEDCVQ VARTHLNPNA
LVVVVTAPPD KTIRKALGRL APVENA
//
