ID E8R414_ISOPI Unreviewed; 311 AA.
AC E8R414;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Methylenetetrahydrofolate dehydrogenase (NADP(+)) {ECO:0000313|EMBL:ADV61601.1};
DE EC=1.5.1.5 {ECO:0000313|EMBL:ADV61601.1};
GN OrderedLocusNames=Isop_1012 {ECO:0000313|EMBL:ADV61601.1};
OS Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B).
OC Bacteria; Planctomycetota; Planctomycetia; Isosphaerales; Isosphaeraceae;
OC Isosphaera.
OX NCBI_TaxID=575540 {ECO:0000313|EMBL:ADV61601.1, ECO:0000313|Proteomes:UP000008631};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43644;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders E., Brettin T.,
RA Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Eisen J.A.;
RT "The complete sequence of chromosome of Isophaera pallida ATCC 43644.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV61601.1, ECO:0000313|Proteomes:UP000008631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43644 / DSM 9630 / IS1B
RC {ECO:0000313|Proteomes:UP000008631};
RX PubMed=21475588; DOI=10.4056/sigs.1533840;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Goker M., Cleland D., Saunders E., Lapidus A., Nolan M., Lucas S.,
RA Hammon N., Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Detter J.C., Beck B., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Isosphaera pallida type strain (IS1B).";
RL Stand. Genomic Sci. 4:63-71(2011).
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DR EMBL; CP002353; ADV61601.1; -; Genomic_DNA.
DR RefSeq; WP_013563890.1; NC_014962.1.
DR AlphaFoldDB; E8R414; -.
DR STRING; 575540.Isop_1012; -.
DR KEGG; ipa:Isop_1012; -.
DR eggNOG; COG0373; Bacteria.
DR HOGENOM; CLU_059363_0_0_0; -.
DR InParanoid; E8R414; -.
DR OrthoDB; 6180at2; -.
DR Proteomes; UP000008631; Chromosome.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.10280; Methylene-tetrahydromethanopterin dehydrogenase, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR015259; Methyl-teptahyd_DH_N.
DR InterPro; IPR037089; Methyl-teptahyd_DH_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF09176; Mpt_N; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ADV61601.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008631}.
FT DOMAIN 28..107
FT /note="Methylene-tetrahydromethanopterin dehydrogenase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF09176"
SQ SEQUENCE 311 AA; 32449 MW; EA98EE113E9633B0 CRC64;
MSEPTVAPKP VKPSILVMLD PDPQPSLFDA VVGIDAGVDH LLRYGGVTVS QVRDLVHGAI
FTRGPADLKR TAIFVGGSDV DAAERLMEAV HAAFFSDFRV STMLDPNGAN TTAAAAIRAG
LKSLGRDHAQ AGPQPLEGIR TAVLGGTGPV GRRVARLAAR LGAQVALGSR DLLRARQAIH
GIAQAAGLPT DRFTPFDRVE VLSEFAPALV VACGAAGVTL LSTAERDALA SSLHVIIDLN
AVPPAGVEGV AVTAKDQPLT PSDPNSPRVW GALGVGGLKM KLHRRVVQML FETSQSTFDA
ETILDVARTM D
//
