ID E8R5R7_ISOPI Unreviewed; 1104 AA.
AC E8R5R7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Sigma54 specific transcriptional regulator, Fis family {ECO:0000313|EMBL:ADV62824.1};
GN OrderedLocusNames=Isop_2246 {ECO:0000313|EMBL:ADV62824.1};
OS Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B).
OC Bacteria; Planctomycetota; Planctomycetia; Isosphaerales; Isosphaeraceae;
OC Isosphaera.
OX NCBI_TaxID=575540 {ECO:0000313|EMBL:ADV62824.1, ECO:0000313|Proteomes:UP000008631};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43644;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders E., Brettin T.,
RA Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Eisen J.A.;
RT "The complete sequence of chromosome of Isophaera pallida ATCC 43644.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADV62824.1, ECO:0000313|Proteomes:UP000008631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43644 / DSM 9630 / IS1B
RC {ECO:0000313|Proteomes:UP000008631};
RX PubMed=21475588; DOI=10.4056/sigs.1533840;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Goker M., Cleland D., Saunders E., Lapidus A., Nolan M., Lucas S.,
RA Hammon N., Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Detter J.C., Beck B., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Isosphaera pallida type strain (IS1B).";
RL Stand. Genomic Sci. 4:63-71(2011).
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DR EMBL; CP002353; ADV62824.1; -; Genomic_DNA.
DR RefSeq; WP_013565112.1; NC_014962.1.
DR AlphaFoldDB; E8R5R7; -.
DR STRING; 575540.Isop_2246; -.
DR KEGG; ipa:Isop_2246; -.
DR eggNOG; COG2204; Bacteria.
DR HOGENOM; CLU_009564_0_0_0; -.
DR InParanoid; E8R5R7; -.
DR Proteomes; UP000008631; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR PANTHER; PTHR32071:SF57; SIGMA L-DEPENDENT TRANSCRIPTIONAL REGULATOR YQIR-RELATED; 1.
DR PANTHER; PTHR32071; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF02954; HTH_8; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR PRINTS; PR01590; HTHFIS.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008631};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 728..957
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000259|PROSITE:PS50045"
FT REGION 683..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 632..659
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 698..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 120767 MW; 8B693FE3697D95E7 CRC64;
MRCGIAAATA GVTVYALVVL YVVATEADIG LRCVFGVEVG QPIDPRFPWR SETPDGPDRP
EVGARIEVIE APGMGSARIG HYGDLVRAQR SMREWRDRGV SEVRVGWSRP ESPGELIWSW
ATLRSRPPDS WLRSLTWLGL VLGILVLGAR VAWKRPDDDA SRLFFAICVI TVGAYSAGYH
WSEIVGYAPL IYLFAFFAVF VPVASLHFYL IFPSPLPWYT RHQRWALGVL YGVPLTYVTL
LWSHMIVLGA VQQPWEWVGS IWPEAVLKEW AVFLIERIRL LALGYVGLAG VVYAACVALL
IARARWAADP REARQIKWIL WASLMSVPLV TILLVRAVWD TTSLNRDPTA WLMFAVSLLY
MIAYAMSITR SKLMQVDEII NRSVAYMAAS VAVGVLYSTF LVVGGLMIGE AMANQTSRLA
VLAGFTAIVA LILTGAARDW FHRLIDRRFR PERYQLDQAL DRISAAVGTM IDRPALARRL
LEAAGDVLRI DWGALYLAED PDMPVSGSTG SGLVGPKPSP LTLAASLGPS PETALLRPDH
PLVQRLGRDP SQRLTIPRAF AHRDEATDAM IALGGEVALA LPGPDSGDAP ASCGALSGVL
ILGPKQSGLP YAEEELAFLG ALASFAALAL RSAATQRSLA QLDAELNRKA EEILRQRRRI
EDLERWLATQ TDVSSLQHAL AGDMVGPHRP VSGETEAGPS PVTHSDGTST SAGLLPFGVT
ERSIDSPIVG SSPAVRRMLR IASKVAQGDA AVLITGESGT GKELLAETIH NAGPRRHGPL
VKVHCAALPP TLLESELFGH VKGAFTGADR DRIGRFQQAE GGTLFLDEIG DINLDVQVKL
LRVLQEKAFE PVGSSRTHKV NVRIVAATHQ DLRDLIRQGR FREDLYYRLN VVPIRTPPLR
ERLEDLPELA ARFLAKHARR LGKPVLSIEP DALAAMLDYH WPGNIRELEN TIERAVVLAE
RSSLSLADLP EEWAWSSAST RRVELATLLA NPSEGNSTLP GTSRVASTSR FLTANSNPTP
RVDSSTQAKS CSIAGEFPPS SSPRGWSSAM VPMEQVLRTD PRDWQRLRLE EALKRAGGNK
SQAARMLGIP RSTLLSQLRK HRLA
//
