ID E8T220_THEA1 Unreviewed; 163 AA.
AC E8T220;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Histidine triad (HIT) protein {ECO:0000313|EMBL:ADU96915.1};
GN OrderedLocusNames=Theam_0948 {ECO:0000313|EMBL:ADU96915.1};
OS Thermovibrio ammonificans (strain DSM 15698 / JCM 12110 / HB-1).
OC Bacteria; Aquificota; Aquificae; Desulfurobacteriales;
OC Desulfurobacteriaceae; Thermovibrio.
OX NCBI_TaxID=648996 {ECO:0000313|EMBL:ADU96915.1, ECO:0000313|Proteomes:UP000006362};
RN [1] {ECO:0000313|EMBL:ADU96915.1, ECO:0000313|Proteomes:UP000006362}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15698 / JCM 12110 / HB-1
RC {ECO:0000313|Proteomes:UP000006362};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Ovchinnikova G., Vetriani C., Woyke T.;
RT "Complete sequence of chromosome of Thermovibrio ammonificans HB-1.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP002444; ADU96915.1; -; Genomic_DNA.
DR RefSeq; WP_013537701.1; NC_014926.1.
DR AlphaFoldDB; E8T220; -.
DR STRING; 648996.Theam_0948; -.
DR KEGG; tam:Theam_0948; -.
DR eggNOG; COG0537; Bacteria.
DR HOGENOM; CLU_056776_1_2_0; -.
DR OrthoDB; 9784774at2; -.
DR Proteomes; UP000006362; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01275; FHIT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR Pfam; PF01230; HIT; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 29..137
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 122..126
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 124
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT BINDING 54
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 116..119
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 126
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ SEQUENCE 163 AA; 18613 MW; 5F9F9D678463B20B CRC64;
MELLWAPWRL SYVSKVGKEE PRGCFICRAA AEHPDRDEEN LLLYKGEKAL VILNRFPYNT
GHLMVCPVRH TGDFTSLLPE ELLEVNRLIQ KSIEVLKRAY NPDGFNVGLN LGRAAGGSVD
THIHFHVVPR WNGDTNFMPV TAGVKVIPQA LDETYRRLKE CWE
//
