ID E8U4Z4_DEIML Unreviewed; 1332 AA.
AC E8U4Z4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Deima_0473 {ECO:0000313|EMBL:ADV66133.1};
OS Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 /
OS LB-34).
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=709986 {ECO:0000313|EMBL:ADV66133.1, ECO:0000313|Proteomes:UP000008635};
RN [1] {ECO:0000313|EMBL:ADV66133.1, ECO:0000313|Proteomes:UP000008635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34
RC {ECO:0000313|Proteomes:UP000008635};
RX PubMed=21677853; DOI=10.4056/sigs.1633949;
RA Pukall R., Zeytun A., Lucas S., Lapidus A., Hammon N., Deshpande S.,
RA Nolan M., Cheng J.F., Pitluck S., Liolios K., Pagani I., Mikhailova N.,
RA Ivanova N., Mavromatis K., Pati A., Tapia R., Han C., Goodwin L., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brambilla E.M., Rohde M., Goker M., Detter J.C., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Deinococcus maricopensis type strain (LB-
RT 34).";
RL Stand. Genomic Sci. 4:163-172(2011).
RN [2] {ECO:0000313|Proteomes:UP000008635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34
RC {ECO:0000313|Proteomes:UP000008635};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Goodwin L., Pitluck S., Kyrpides N.,
RA Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G., Zeytun A.,
RA Detter J.C., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Pukall R., Gehrich-Schroeter G.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Deinococcus maricopensis DSM 21211.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP002454; ADV66133.1; -; Genomic_DNA.
DR RefSeq; WP_013555638.1; NC_014958.1.
DR STRING; 709986.Deima_0473; -.
DR KEGG; dmr:Deima_0473; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_0_0; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000008635; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:ADV66133.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ADV66133.1}.
FT DOMAIN 25..96
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1332 AA; 148078 MW; 55DD702C23ED2188 CRC64;
MTVPADAAPH IHLPDGSCCT PKRFAHLHQH TQYSLLDGAA KLKDLLKWAK EVTPDGCTPA
LAMTDHGNMH GAVHFYNYAT GMGVKPIIGY EAYVVPGVGT RRERTRGQDG EKGIFHLTLL
ARDFEGYQNL CRLSSRGYTE GYYYKPRIDH ELLQEHHKGV IAFSGCLGSE VQQLLLQGRE
ADAKQRLMWY RDLFGENYFI EIQDHGLPEQ KRNNPILRAW AQELGIGMVA TNDGHYVKKS
DATAHETLLA IQTKATLADE NRFKFPCDEF YVKNLEEMQA ALPVSEWGEE PFDNTAMIAD
LCNVDLPVGK KRVYQMPALP IPEGRTMAEE LRVQTYAGSL KRYPHHVTEG LLRAYAKRSL
DALGADDAAA VLRRVPGCDA STCDVDTLLT LVAFMGSVWE ARGKAAGEKF TKYPALEELE
AEAASGQLPF YALRDWRRAE GAETVTDTDI QLDPGSVEHE SACAHHRHAL VLLRRAEYEL
SVINNMGFPD YFLIVADYIN WAKDHGISVG PGRGSGAGSL VAYAIRITNL DPLEFELLFE
RFLNPDRISM PDFDIDFNDA RRGEVITYVQ QKYGDDKVAQ IATFGTMASK ACLKDVARVM
GLEYAKVDKV SKLIPIKFGK SYSLEQARES VPDIQQMLDE DAQLREAYEF AQKLEGLTRH
ASVHAAGVVI GKTQLTDLVP VMRDTSGEGM VCQYDMKAVE DIGLIKMDFL GLRTLSFLDE
AKRIMRESKG IEVDFDAIPF DDEATFDLLS RGDTKGVFQL EGAGIADASR RLKPRRLADI
IALSALYRPG PMENIPTYVR RHHGLEQVDY VRDGFPNSAQ WLEKILAETY GIPVYQEQIM
QIASEVAGFS LGGADLLRRA MGKKDAEEMK RQRQIFVDGA EGNGVPKDEG NKLFDLLDAF
ANYGFNKSHS AAYGVITYQT AWLKANHPVE FMAALLTVER RDSDKVAEYA SDARKMGVTV
LPPDINRSGA DFKVVGQDIY FGLYAIKGLG ENAVLRILDE RERGGRFRSL ADFCARIDNK
TCNRKGLESL IKSGAFDAFG ERQQLLSSLE DAIAWAQGAA AMLNSGMDAL FGMAETAPEP
KLRANVEPLS ELAKLALEKE ALGLYISGHP LEQHEGLREA ASTRIADLDD WFFTQPQTGG
RNRVKAVLAG MIEGVVKKPT KSGGMMARFN LADETATIEL VAFSRAYDRI QDKLINDTPA
LVIVELESEE GSLRAIAEEV VPAEALADIP KVMYVNIDLD QTSTDALADF QSYLDEHAGT
LPTYFRFESG DHYMVYQLDK PIGGPDSMRV VNSTFPWARA YLAMDTQMIL NRYAPKPPAW
QQRQNAARTL QA
//
