ID E8U6F7_DEIML Unreviewed; 669 AA.
AC E8U6F7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:ADV66646.1};
DE Flags: Precursor;
GN OrderedLocusNames=Deima_0993 {ECO:0000313|EMBL:ADV66646.1};
OS Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 /
OS LB-34).
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=709986 {ECO:0000313|EMBL:ADV66646.1, ECO:0000313|Proteomes:UP000008635};
RN [1] {ECO:0000313|EMBL:ADV66646.1, ECO:0000313|Proteomes:UP000008635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34
RC {ECO:0000313|Proteomes:UP000008635};
RX PubMed=21677853; DOI=10.4056/sigs.1633949;
RA Pukall R., Zeytun A., Lucas S., Lapidus A., Hammon N., Deshpande S.,
RA Nolan M., Cheng J.F., Pitluck S., Liolios K., Pagani I., Mikhailova N.,
RA Ivanova N., Mavromatis K., Pati A., Tapia R., Han C., Goodwin L., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brambilla E.M., Rohde M., Goker M., Detter J.C., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Deinococcus maricopensis type strain (LB-
RT 34).";
RL Stand. Genomic Sci. 4:163-172(2011).
RN [2] {ECO:0000313|Proteomes:UP000008635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34
RC {ECO:0000313|Proteomes:UP000008635};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Goodwin L., Pitluck S., Kyrpides N.,
RA Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G., Zeytun A.,
RA Detter J.C., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Pukall R., Gehrich-Schroeter G.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Deinococcus maricopensis DSM 21211.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; CP002454; ADV66646.1; -; Genomic_DNA.
DR RefSeq; WP_013556151.1; NC_014958.1.
DR AlphaFoldDB; E8U6F7; -.
DR STRING; 709986.Deima_0993; -.
DR KEGG; dmr:Deima_0993; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG1226; Bacteria.
DR eggNOG; COG5207; Bacteria.
DR HOGENOM; CLU_005126_9_0_0; -.
DR OrthoDB; 9793589at2; -.
DR Proteomes; UP000008635; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51201; RCK_N; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008635};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..669
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003232229"
FT TRANSMEM 26..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 431..553
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 587..669
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
SQ SEQUENCE 669 AA; 69262 MW; A5D1B1309F5B7F04 CRC64;
MTRAFALALA LSGAASASTD GGTHALLGQL TLLLLVAAFA AYLSFRAGLV PIIGFLLAGV
LVGPSVLGVI DDPALISTAS EIGVMLLLFA IGIEFSLERL ARIGRAIFLG GGAQVALTVA
ATTLLLTLLG VSVPNALFTG CLLALSSTAI VMKLLADRGR TGSEAGQLSL AVLIFQDLAV
VVMVLLVPMM AGQGGGPLGV LLALAKAGGI VAAVLLLARR VLPKLLEVVA RTCSPEIFLL
TIVAVCFGTA YLTSLAGVSL ALGAFLAGLI VSESRFGRQA LGEILPLQIL FSAAFFLSVG
LQLDVRFLLT NLPLVLLAVV LIAVLKTAVT AASLRLLGTS TLTATATALL LAQIGEFSFV
LESTGRALGL TPAGLGERGT QTFIAATVLL MAFTPLLARL GERLPARTPR PAPAPAAPDT
GHGPLGHLRD HVILAGFGAH ARRVARALHR QHQPFGVLTL SPGGAADVAE HDVPVVIGDY
ARAALLSEAG VAHARALVVA DDAPDMAARV ISVARTLNPD LTIVAHVDRL DDADELRHAG
ATHVLTGHDE VALGVLHHLT PGEPGRAHLH RALHGPLPVA LDADQLGMCE HTAQTTCVTP
EADVCPECVA LGDRWVHLRV CMTCGHVGCC DSSKNKHATA HHHASGHPII RSLERGETWA
YCYPHDLTK
//
