ID E8WYQ0_GRATM Unreviewed; 500 AA.
AC E8WYQ0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ADW67648.1};
GN OrderedLocusNames=AciX9_0577 {ECO:0000313|EMBL:ADW67648.1};
OS Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Granulicella.
OX NCBI_TaxID=1198114 {ECO:0000313|Proteomes:UP000000343};
RN [1] {ECO:0000313|Proteomes:UP000000343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP5ACTX9 {ECO:0000313|Proteomes:UP000000343};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Ovchinnikova G., Pagani I., Rawat S.R., Mannisto M.,
RA Haggblom M.M., Woyke T.;
RT "Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP002480; ADW67648.1; -; Genomic_DNA.
DR RefSeq; WP_013578976.1; NC_015064.1.
DR AlphaFoldDB; E8WYQ0; -.
DR STRING; 1198114.AciX9_0577; -.
DR PaxDb; 1198114-AciX9_0577; -.
DR KEGG; acm:AciX9_0577; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_4_3_0; -.
DR OrthoDB; 100851at2; -.
DR Proteomes; UP000000343; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF12; BLL1977 PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000000343}.
FT DOMAIN 4..139
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 182..414
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 500 AA; 56320 MW; 2AB6182F0020B5B3 CRC64;
MLSRGKVVLF YPPYDGPPLG APLSLLALAG TLREANFEVV LIDAAIEDHH LDRIEEECAS
ALCIGISVLT GPMIRGAIIA AQHVKRTNPS VSVVFGGWHP TLCPESTLRE PYVDIVVRGQ
GELTIVELAV ALAEKKPLDF ITGISWKKNG RLIENFERRV QPVDTFAQPA FDMTDFDAYE
KKSGKRELAY ATSIGCPYAC NYCTDMVVYK RRFNAYAAEH VVAELTGLVK RYRITHVALL
DSNFPVDLKR AIAIARGIVD SGVKFAWTFQ ASTDFICRMS QEEVQLLADS GVRYMGFGTE
STSKAVLKMM NKRHQRVDEM YETARKAELA GIRVNFNLIL GYPGETEADR LETFRTMSDI
GRHFKNVRFS PNIFTPYPGI PIWPQLRELG VVEPQTLEEW ETMPLGANLL PWLRGRELAR
LNRMLAYFLL LSQVSRRRSS SSTLRRILGM LITAPIRWRL TSSRFSFPWE IWLSQLSEQI
VKRRSLITGQ ALPAVESANA
//
