ID E8X553_GRATM Unreviewed; 730 AA.
AC E8X553;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Glutamate carboxypeptidase II {ECO:0000313|EMBL:ADW68317.1};
DE EC=3.4.17.21 {ECO:0000313|EMBL:ADW68317.1};
GN OrderedLocusNames=AciX9_1255 {ECO:0000313|EMBL:ADW68317.1};
OS Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Granulicella.
OX NCBI_TaxID=1198114 {ECO:0000313|Proteomes:UP000000343};
RN [1] {ECO:0000313|Proteomes:UP000000343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP5ACTX9 {ECO:0000313|Proteomes:UP000000343};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Ovchinnikova G., Pagani I., Rawat S.R., Mannisto M.,
RA Haggblom M.M., Woyke T.;
RT "Complete sequence of chromosome of Acidobacterium sp. MP5ACTX9.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; CP002480; ADW68317.1; -; Genomic_DNA.
DR RefSeq; WP_013579640.1; NC_015064.1.
DR AlphaFoldDB; E8X553; -.
DR STRING; 1198114.AciX9_1255; -.
DR PaxDb; 1198114-AciX9_1255; -.
DR KEGG; acm:AciX9_1255; -.
DR eggNOG; COG2234; Bacteria.
DR HOGENOM; CLU_005688_2_1_0; -.
DR OrthoDB; 233977at2; -.
DR Proteomes; UP000000343; Chromosome.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:UniProtKB-EC.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000313|EMBL:ADW68317.1};
KW Hydrolase {ECO:0000313|EMBL:ADW68317.1};
KW Protease {ECO:0000313|EMBL:ADW68317.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000343};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..730
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003234387"
FT DOMAIN 164..248
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 348..559
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 623..725
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 125..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 77980 MW; BAA8C03B77E1DE8E CRC64;
MNRPAILPVL LALSSAAALA QSATQSSVPP APTSVFGYKD FSQQAKWDAA FQAIPDSKLA
GEHLKTLTKA PHWASSPEDY ATAEYVAAKF KAAGLQTEIV PYKVLLNKPV KIVIEAFDAT
GAKLMSGPSP EHVDPTKDGG DPFQDDPRIL PAFNGSSPSA DIAAEVVYAN YGTPADFKKL
ADLGVDVKGK IVIVRYGANY RGIKVYDAQK AGAAGVLIFS DPEDDGYFRG DKYPKGPYRP
DSAVQRGAVQ FLPIYPGDAT TPGIASTPNL PDSQRIPADK IQANWPSIPS NPLSYKDAAP
ILEALGGPAA PHAWQGALPF AYHVGGGPKI MVHMHLEQDT KLRTIWDVIG TIPGTDPAEK
NDWVVAGNHR DAWVYGAVDP NSGTAAMLET VHGLGDLLKQ GWKPKRTIVI GSWDAEEEGL
IGSTEWVEAH PTQLRNAVAY FNTDVGVSGP NFNASAVPSL KQFVREVTRE VPSPAGGTVY
DQWLKGQTDR RNESEDEGGA TRGARPAGRN GGTAGEIRIG DLGSGSDYTP FLQHQGVPAT
DIGSGGPYGV YHSVFDNYNW FIKNADPTFV YEQQQARVFG LEILHMADAD VLPYDYQAYG
TQLKGYIEAA KSRSSAMGLD FAALESAANR FAAAGVVIRQ RQLTPSNTAT LNTALRSAED
ALLDPAGLPH RAWYKHTIYA PGEFTGYAAV VIPGVNEGID AIDKARTQTQ IESLTAAVNR
SAAILEAAAK
//
