ID E9ADF4_LEIMA Unreviewed; 1499 AA.
AC E9ADF4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CBZ12244.1};
GN ORFNames=LMJF_27_1770 {ECO:0000313|EMBL:CBZ12244.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ12244.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CBZ12244.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CBZ12244.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796423; CBZ12244.1; -; Genomic_DNA.
DR RefSeq; XP_003721983.1; XM_003721935.1.
DR STRING; 5664.E9ADF4; -.
DR EnsemblProtists; CBZ12244; CBZ12244; LMJF_27_1770.
DR GeneID; 12982767; -.
DR KEGG; lma:LMJF_27_1770; -.
DR VEuPathDB; TriTrypDB:LmjF.27.1770; -.
DR VEuPathDB; TriTrypDB:LMJFC_270026600; -.
DR VEuPathDB; TriTrypDB:LMJLV39_270024400; -.
DR VEuPathDB; TriTrypDB:LMJSD75_270024600; -.
DR eggNOG; ENOG502QVQN; Eukaryota.
DR HOGENOM; CLU_248784_0_0_1; -.
DR InParanoid; E9ADF4; -.
DR OMA; ALCISYP; -.
DR Proteomes; UP000000542; Chromosome 27.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR PANTHER; PTHR14859; CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR; 1.
DR PANTHER; PTHR14859:SF1; PGAP2-INTERACTING PROTEIN; 1.
DR Pfam; PF10277; Frag1; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 72..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 806..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..869
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 969..991
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1003..1023
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1044..1062
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 385..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1499 AA; 168451 MW; C0AD6E65A7AFE65C CRC64;
MNTYRSSLPR LCVGMCLLAS TGCPHTSLAC VSLVLVLPRL FASLLLHHTP FYAVRAKPAC
VYRYSGFLPV PLLFLCSCFV PALLTARILL PLCACLDIHT TTQVEQSMRH VFYIPSSYAA
LIYALTTGYA LFACLYMAGV LHWRDIIVTS CGEDHYEFWP SISATVGEMM PERQTWRVAF
TLCVPFRVSA SMSLFNVFWQ RASRGMEDLY SFRRSWKAFL SSNAFLALLA LGTDTWRFIG
ASVYSVVSAK ESLTYHNLGI CPYLPFCLVL QAAVTMLVRR NQFNTAIYPT PQDATASYAV
KRVCLCVEVV AAVGIVCCYS HYLRTCANGS LSLSSICEWV FSIFNIIFDG SAWFDLKQEG
WWLSGPPGFY RKLYARRVHR ASGAASTPQV KGAKDGTKDG HAGGDGDVAV TVPVPNGDGD
ATPECDSGAA VEDTVPLTSP PRTTTGEFFL DRNVILHRFS FCSAPSRLSL WICDVYWAHM
FFEMAVHLIQ HMYFMPLIAM SLSWEVSSVL VLGAPCLLRI SAFRRWATGP CICAQTWLKP
SHVPIGLSYR TAPMYILFYA LASISHFQQL IRWNPGKKIL VVAVGPLLLS LALYTRFLYP
STVTLKRAWA EGDEDSRRMT MTLPLGLVLC MLLRVQHVGV SPLFTNPFYG SIYGILLGLI
FTTIIYRRAM MGNTLKEEVP QQCSAPSATQ MSSTTLLMRD LHRGGDAEEI KRFSVSTAGG
GRDASHTDRI GQKVADGVDI RGVHFSLSQV DEASESTVPA IATLYTPPSP ALLGVLCGCI
TSIGITFLSC PNYIPRMLAV EPFPANLVIA GIFTAGLHYS TDVLPLALVL LRPKGHPDIV
RRALYAVVGG SWSRFGVLLA LNTTLMLFAT RQTNFTYEVP HDGYPVTMDT PRAEVDVKYW
EAQETFWGSK HVAFMGGLGF TFCIGVLFPF AMEVTWAHQR DRRFAQIAEA ADAEAVISHE
CSFFMSFEFT WLLCVTSSCV LHALCISYPF VPMAWLVREK SRPLILAHVG TLYLTAWIVA
RRIRSSRAVA AAITDVAAAR KQRSIQMMVI IVIVFFFVWV FIERVTMGGA DASFPANKKT
AIQFQEEVLH LHKMLIELRR ARNIITDPYM KKFETIYYQE RFEDAMASMD KNITESKDGV
PVDPKLNLTH LSHADRIDVW EAAKAMTFFS GAIWTVHFGL DNYNVDSFSR IVEELRKTEA
SVIGLLESDS MHLTNGNRDM VEYVSYHLGF RYTDYGPTVL DNTYGCALVT RYPILDVRRY
VIPSPLGELA CVIHAVLDVY GVPVHTYVGH FGNTEHWADG LLQSQFLGRL VLSNPGPSMW
LGYLVTHPGM KERYQEYTDP KAPGKFRDAG LEMYRQHPWT RLWDRGGYEE ELPVPTKQPV
KKTNFDIEVK FQYVGYLEEG MQVDSHFRRP PADKPPRHFY YNDTGRYTNA HPRFEFMDRY
CQYCLYKTGA TADEVVGDAG KLQPYQVRLF DWWRIVDHGV ELLSDTEIQV IQLAFEKRR
//
