ID E9AE43_LEIMA Unreviewed; 473 AA.
AC E9AE43;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Putative Tob55 {ECO:0000313|EMBL:CBZ12522.1};
GN ORFNames=LMJF_29_1820 {ECO:0000313|EMBL:CBZ12522.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ12522.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CBZ12522.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CBZ12522.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
CC -!- SIMILARITY: Belongs to the SAM50/omp85 family.
CC {ECO:0000256|ARBA:ARBA00010913}.
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DR EMBL; FR796425; CBZ12522.1; -; Genomic_DNA.
DR RefSeq; XP_003722264.1; XM_003722216.1.
DR AlphaFoldDB; E9AE43; -.
DR STRING; 5664.E9AE43; -.
DR EnsemblProtists; CBZ12522; CBZ12522; LMJF_29_1820.
DR GeneID; 12981044; -.
DR KEGG; lma:LMJF_29_1820; -.
DR VEuPathDB; TriTrypDB:LmjF.29.1820; -.
DR VEuPathDB; TriTrypDB:LMJFC_290027200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_290025700; -.
DR VEuPathDB; TriTrypDB:LMJSD75_290025900; -.
DR eggNOG; KOG2602; Eukaryota.
DR HOGENOM; CLU_570527_0_0_1; -.
DR InParanoid; E9AE43; -.
DR OMA; WISMGIF; -.
DR Proteomes; UP000000542; Chromosome 29.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.160.50; membrane protein fhac: a member of the omp85/tpsb transporter family; 1.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR039910; D15-like.
DR PANTHER; PTHR12815:SF18; SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG; 1.
DR PANTHER; PTHR12815; SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF01103; Omp85; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 253..440
FT /note="Bacterial surface antigen (D15)"
FT /evidence="ECO:0000259|Pfam:PF01103"
SQ SEQUENCE 473 AA; 52514 MW; 3D8F065AE1C6AA4E CRC64;
MTDTMQQTVN ICEDDLSAAL KMPIRAHVRL VGIEGTHPDV VASDLETIKR CRTMEEAVEA
ITEIRSRWIA AGIFRNVKYN FEPTADGERN DICVRLDVVE EKPKKSIGVF TTDTSIPEIT
VALENILGGR YSVKGNYIPP ASRVHSISFS FLSNVPLIGQ SAEYYIGRKT ENKTYHLANS
ERVEEVKATT TNRKGKLASE FSVGLQRRTL LTKHMKSIPL EDAVDFSATD KGYARHQLTI
TDVAHHANPF LYNMYPLPIY GSQVSLCNEF AGGPMGGDFT FLKSEFQGSK YIPLGPFFSL
QLSAKLAGIY PFFGSRIPLN DRLFLSNSHV RGFKSVGPST LDWEGNVSRF AATGGNALWA
TSLSLNFPFL FFPNNGIASM HLFANAGHVR MIESLDALKD SYRWLRDCAC SVGAGIVITR
IPIFGVAPSG RFELNMSIPL GIDKQGNIVC RNGRKSLFDR FRFGLVWSSN FSF
//
