ID E9AFI3_LEIMA Unreviewed; 931 AA.
AC E9AFI3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Putative DNA repair protein RAD2 {ECO:0000313|EMBL:CBZ12987.1};
GN ORFNames=LMJF_35_3590 {ECO:0000313|EMBL:CBZ12987.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ12987.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CBZ12987.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CBZ12987.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR796431; CBZ12987.1; -; Genomic_DNA.
DR RefSeq; XP_003722753.1; XM_003722705.1.
DR AlphaFoldDB; E9AFI3; -.
DR STRING; 5664.E9AFI3; -.
DR EnsemblProtists; CBZ12987; CBZ12987; LMJF_35_3590.
DR GeneID; 12980515; -.
DR KEGG; lma:LMJF_35_3590; -.
DR VEuPathDB; TriTrypDB:LmjF.35.3590; -.
DR VEuPathDB; TriTrypDB:LMJFC_350046200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_350043400; -.
DR VEuPathDB; TriTrypDB:LMJSD75_350042900; -.
DR eggNOG; KOG2520; Eukaryota.
DR HOGENOM; CLU_314371_0_0_1; -.
DR InParanoid; E9AFI3; -.
DR OMA; IWIAQFR; -.
DR Proteomes; UP000000542; Chromosome 35.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09868; PIN_XPG_RAD2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR039436; Asteroid_dom.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081:SF54; FI23547P1; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF12813; XPG_I_2; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00841; XPG_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 1..96
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 648..716
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 161..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..476
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 99319 MW; 21EA02F1F524EDA7 CRC64;
MGVHGLWRLL DSFGVVVQPD ELKGKRVAID ASIWIAQFRA RVAPGEDTEH KVLEGFLARI
LKLLFYGIRP VFVFDGPASS SKGAEHHRRT MQRARTAQAL VKRRARQILV AQVAAGELEV
EDLKAAMSSG ACAENNAVKA EKDSDAAAAS MAASAAEGTC LSETVPRGGG TDRALGATSS
ARGSAIHGGK RPREASEEVL PLPRPHCRRH CLRQRRLAPD AVSATITQSF LRDVEGLLEE
RTRHEACVLQ NALQGTSTSL FMGPRRAVDE NSDAVAGVIT SGHLQPLHPH CTAAVVLVSG
DSQERDETGC VVISDSESDA EAVSSTSCIV TSTDGEEGSD VEEVVLVENA GGPGRADAPE
GALWLPSSAC SPSAATAVLH SGDMTRFLNA LSQSTCTPPP ELMPPTTASE RTPSVIPSSS
SSSSAALSVS ADEGIATDPG SSSTRSSKSP AFPSDGSSEE ADGFTDGGDG DDRDDSEFAW
EPFTQRRHLA QLLRPQEQES ESHPHSSSSA AAQMVTASFA GPPRTDATTV GKEDEYEDDY
APVRAVEMFS RRRTAPVPLP MVGSISRNGE SEKGNCTISV SAPHHPNAVK GAISEVAGAP
HRKSAEVHSS STDRASSLGG VPPHGGGAAR THRVVIPFEL LNVVELLDCC GVPYVLSPAE
ADAQCAFLAR CGLVDAVFTE DSDVLVHGAT RVLRGFFAQS KNVVAYEQTH LSACGITKTV
LVALASLLGC DYTEGVCGIG LVGALEALVV AWTTAESAEA GAASSSAVLH LLRRWALLVQ
RPPRSWQEVD DHMTILQFAL LQVHVAQWRT LEQRACFPEA HAVEAFFDAK VDLDTTPFQW
LPPDWQRIRV FAGALGALSS PWLVQRYELA RKECLRREET AAKERASLTA GQRQLTEYGV
QERVRARWAF QRQPPKHAAA LAKLRAVQQM Q
//