ID E9AID5_LEIBR Unreviewed; 231 AA.
AC E9AID5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Cytochrome c oxidase assembly factor-like protein {ECO:0000313|EMBL:CBZ14579.1};
GN ORFNames=LBRM_20_5020 {ECO:0000313|EMBL:CBZ14579.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CBZ14579.1};
RN [1] {ECO:0000313|EMBL:CBZ14579.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CBZ14579.1};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CBZ14579.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CBZ14579.1};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
RN [3] {ECO:0000313|EMBL:CBZ14579.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CBZ14579.1};
RA Aslett M.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SCO1/2 family.
CC {ECO:0000256|ARBA:ARBA00010996}.
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DR EMBL; FR798995; CBZ14579.1; -; Genomic_DNA.
DR RefSeq; XP_003723051.1; XM_003723003.1.
DR AlphaFoldDB; E9AID5; -.
DR STRING; 5660.E9AID5; -.
DR GeneID; 12983530; -.
DR KEGG; lbz:LBRM_20_5020; -.
DR VEuPathDB; TriTrypDB:LbrM.20.5020; -.
DR VEuPathDB; TriTrypDB:LBRM2903_200064600; -.
DR InParanoid; E9AID5; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd02968; SCO; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR003782; SCO1/SenC.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12151:SF3; C OXIDASE ASSEMBLY FACTOR, PUTATIVE ELECTRON TRANSPORT PROTEIN SCO1_2, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR12151; ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER; 1.
DR Pfam; PF02630; SCO1-SenC; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|PIRSR:PIRSR603782-1};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR603782-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR603782-1}.
FT BINDING 67
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000256|PIRSR:PIRSR603782-1"
FT BINDING 71
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000256|PIRSR:PIRSR603782-1"
FT BINDING 182
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000256|PIRSR:PIRSR603782-1"
FT DISULFID 67..71
FT /note="Redox-active"
FT /evidence="ECO:0000256|PIRSR:PIRSR603782-2"
SQ SEQUENCE 231 AA; 26536 MW; 8646CB0AFB8378B7 CRC64;
MNWYENCKLE KLELAPDFQS MQSVSLKPKT QLGGPFRLRE SRTGKYITND ELFQDKWTLL
YFGFSKCAEI CPSTLKFISE VMRVCDAKYG PDSELAAEER KLQAVFLSID FIRDNPEVVE
QLVRKYDPRV RGLCGTREEV DAAARAWRVY YSSVDETSEE RDAREAAGVA VPEIDDTYQL
DHSSAIYLVG PDGKMKDFFF KEMGVEDIVS RVGIHFSDIY GFSDTRQTPR K
//
