ID E9CLK2_9GAMM Unreviewed; 618 AA.
AC E9CLK2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=recQ {ECO:0000313|EMBL:EFW12514.1};
GN ORFNames=SSYM_1123 {ECO:0000313|EMBL:EFW12514.1};
OS Serratia symbiotica str. Tucson.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia; Serratia symbiotica.
OX NCBI_TaxID=914128 {ECO:0000313|EMBL:EFW12514.1, ECO:0000313|Proteomes:UP000013568};
RN [1] {ECO:0000313|Proteomes:UP000013568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson {ECO:0000313|Proteomes:UP000013568};
RX PubMed=21266540;
RA Burke G.R., Moran N.A.;
RT "Massive genomic decay in Serratia symbiotica, a recently evolved symbiont
RT of aphids.";
RL Genome Biol. Evol. 3:195-208(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; GL636107; EFW12514.1; -; Genomic_DNA.
DR AlphaFoldDB; E9CLK2; -.
DR HOGENOM; CLU_001103_14_3_6; -.
DR Proteomes; UP000013568; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EFW12514.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000013568}.
FT DOMAIN 42..210
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 231..379
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 539..618
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 618 AA; 69297 MW; 65B16BEA8BFA0D78 CRC64;
MPIKMGMCVS TTAVINRELR VTQVLRDTFG YQQFRPGQQA IINAAIEGQD CLVVMPTGGG
KSLCYQIPAL VMDGLTLVVS PLISLMKDQV DQLLAYGVSA ACYNSTQTRE QQLAAMAGCR
SGQIKLLYIA PERLMMDSFL DSLGRCPPVI LAVDEAHCIS QWGHDFRPEY RALGQLKQRF
PAMPVIALTA TADESTRGDI VRLLALHKPL VQVSSFDRPN IRYTLVEKFK PLDQLWHFVQ
GQRGKSGIIY CNSRAKVEDT TARLQSRGLS VGAYHAGLDN DRRAQVQEAF QRDDLQVVVA
TVAFGMGINK PNVRFVVHFD IPRNIESYYQ ETGRAGRDGL PAEALLLYDP SDMAWLRRCL
EEKPAGQQRD IERHKLNVMG AFAEAQTCRR LVLLNYFGEG KHQDCGNCDI CLDPPKRYDG
LEDARKALSC VYRVGQRFGL GYIVEVLRGS NNQLMREYGH NQLPVYGIGH DRSTEHWISV
LRQLIHLGFI TQNITMHSAL QLAEAARPVL RGEVALQLAV PRIQSLRPRS SANQKSYGGN
YDRKLFAKLR KLRKSIADEE NIPPYVVFND ATLLEMVEQM PITAGDLLSI NGVGQRKLVR
FGTSFMAMIR DHLNNDED
//
