ID E9CSI2_COCPS Unreviewed; 203 AA.
AC E9CSI2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=DNA repair helicase RAD25 {ECO:0000313|EMBL:EFW22642.1};
DE Flags: Fragment;
GN ORFNames=CPSG_00541 {ECO:0000313|EMBL:EFW22642.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR EMBL; GL636486; EFW22642.1; -; Genomic_DNA.
DR AlphaFoldDB; E9CSI2; -.
DR STRING; 443226.E9CSI2; -.
DR VEuPathDB; FungiDB:CPSG_00541; -.
DR VEuPathDB; FungiDB:D8B26_006237; -.
DR HOGENOM; CLU_1351759_0_0_1; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EFW22642.1};
KW Helicase {ECO:0000313|EMBL:EFW22642.1};
KW Hydrolase {ECO:0000313|EMBL:EFW22642.1};
KW Nucleotide-binding {ECO:0000313|EMBL:EFW22642.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497}.
FT DOMAIN 99..202
FT /note="Helicase XPB/Ssl2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13625"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 203
FT /evidence="ECO:0000313|EMBL:EFW22642.1"
SQ SEQUENCE 203 AA; 22594 MW; D0C1458A334A2D29 CRC64;
MPPKRKAVDG SRVGRASKRA TPVPSSTPQS VLSDDDYTDP GVQDSDVDGD NIKKVVEKFS
LQTFSRDKKS QVLKQDPHFG YKDFSSLPLK PDHANRPLWI EPLKGTITLE SFSPLASQAQ
DFLTTIAEPL SRPTHLHEYR LTGNSLYAAV SVGLLPADII NFLDRLSKTP LPETIKQFIV
NFTKSYGKIK VVLKHNRFSV ESS
//
