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Database: UniProt
Entry: E9CZN0_COCPS
LinkDB: E9CZN0_COCPS
Original site: E9CZN0_COCPS 
ID   E9CZN0_COCPS            Unreviewed;      1072 AA.
AC   E9CZN0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=Forkhead domain containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CPSG_03308 {ECO:0000313|EMBL:EFW20133.1};
OS   Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN   [1] {ECO:0000313|Proteomes:UP000002497}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
RN   [2] {ECO:0000313|Proteomes:UP000002497}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA   Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA   Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA   Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA   Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA   Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Coccidioides posadasii strain Silveira.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   EMBL; GL636489; EFW20133.1; -; Genomic_DNA.
DR   AlphaFoldDB; E9CZN0; -.
DR   STRING; 443226.E9CZN0; -.
DR   VEuPathDB; FungiDB:CPSG_03308; -.
DR   VEuPathDB; FungiDB:D8B26_003421; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   HOGENOM; CLU_008570_0_0_1; -.
DR   OMA; FRCETEG; -.
DR   Proteomes; UP000002497; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00059; FH_FOX; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR045178; Fhl1/FHA1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR21712:SF29; PRE-RRNA-PROCESSING PROTEIN FHL1; 1.
DR   PANTHER; PTHR21712; UNCHARACTERIZED; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002497}.
FT   DOMAIN          425..458
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   DOMAIN          700..788
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        700..788
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          243..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          777..869
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          886..985
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..262
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..543
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..564
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..597
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        615..645
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        792..807
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        817..855
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        910..929
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        946..981
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1072 AA;  116751 MW;  9EAB3EEF28B48D62 CRC64;
     MAASLLGQRP HDAASERSAM DLQVDRCEQS KPPAASDVTP KLEASNNATA DQLKAVSESA
     FLALSDDYKK QTEREKQNAA SALLAQLLSS KPLNNSPEPD QNQSSTEMEL DEKIPQSRNP
     SPRPSPQTQL NGDNPPIEQA PPPTCAQADA TLDTSEAQKA TEDNLMPEAS QEDSIEREHN
     LILDAIQSNA KANPDFIPMF SDFTPLPAAR SAKEALLQSE ILTDAYFGAV GGPTPRIVGY
     PELPTQKDAK GTTNDSGSVS GSEPRIQAYA KLEFDDGHFY VNTYSFILGR DNGNGVRTPK
     RINPDNNHTI MGSVISDTGG IMGFDPDVPQ HCPPQMSWKS SNSSNGHHSH PMLHMTQAEP
     DMSTPVEPPR VMKDYNALAM ESLQNGNEPK RVDTLALLPT PDSCPIIPIH PPASANGVPS
     SHRGISRKHV KIAYNFHRNV FEMEVMGRNG AFMGADWLAP GQVRPLHSGD FIQIGGVRVR
     FLLPDVPIGG TGSEATESPV PESNEAARSR PEGGSAKIES EGEADNSGGE DSARNKEAGK
     VKVKKLTVTV SGQKPSTEES QTPQPARRRG PGRPPKDGIM SKRERAEIAR EQKLAARREA
     NGGVTPPPTT KSKASKSGKD GEAEDQPAVK PEKRKYTKRK RPDSAPGDSV VQSIEGGDGN
     IAPGQEEPIK PAPVKKRKPS RSPSPDYPPE SFYTPKELAK PPYNYAVLIY DALSESPTPM
     TLKQIYRALK LKYPYFRFRC ETEGWTSSVR HNLNGNNHLF MHAERDGKGW SWKLIPGASV
     DKEKKRRPSP PPQDITNHNN QPFLPPSAVP QYTIPHGMPA QHPPPQYPYQ PITQHPTPMA
     PPPLPPPPPA RRANPFPFTL PHLPQTVLPE HDLPRPFSLL RSPVYSSPYS STPPPPHFPH
     PRHRRAPPQP PPQRRQPPPS APVAPPPQNY NAPSIIKFQS QPYNAVPHPS QPPPQAPPPP
     PPAVPIHPMP PAPPPPPQNT SPISSLSLIN QDPAFLSRAN QAIDNFEAVL MEDYEDQEYI
     KKVLRSARDR VLNGAKESSF PGGEPKDEAV IINALRGIIG QLTGDQSQAG IP
//
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