ID E9CZN0_COCPS Unreviewed; 1072 AA.
AC E9CZN0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Forkhead domain containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CPSG_03308 {ECO:0000313|EMBL:EFW20133.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; GL636489; EFW20133.1; -; Genomic_DNA.
DR AlphaFoldDB; E9CZN0; -.
DR STRING; 443226.E9CZN0; -.
DR VEuPathDB; FungiDB:CPSG_03308; -.
DR VEuPathDB; FungiDB:D8B26_003421; -.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_008570_0_0_1; -.
DR OMA; FRCETEG; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00059; FH_FOX; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR045178; Fhl1/FHA1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR21712:SF29; PRE-RRNA-PROCESSING PROTEIN FHL1; 1.
DR PANTHER; PTHR21712; UNCHARACTERIZED; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497}.
FT DOMAIN 425..458
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 700..788
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 700..788
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..855
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..929
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..981
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1072 AA; 116751 MW; 9EAB3EEF28B48D62 CRC64;
MAASLLGQRP HDAASERSAM DLQVDRCEQS KPPAASDVTP KLEASNNATA DQLKAVSESA
FLALSDDYKK QTEREKQNAA SALLAQLLSS KPLNNSPEPD QNQSSTEMEL DEKIPQSRNP
SPRPSPQTQL NGDNPPIEQA PPPTCAQADA TLDTSEAQKA TEDNLMPEAS QEDSIEREHN
LILDAIQSNA KANPDFIPMF SDFTPLPAAR SAKEALLQSE ILTDAYFGAV GGPTPRIVGY
PELPTQKDAK GTTNDSGSVS GSEPRIQAYA KLEFDDGHFY VNTYSFILGR DNGNGVRTPK
RINPDNNHTI MGSVISDTGG IMGFDPDVPQ HCPPQMSWKS SNSSNGHHSH PMLHMTQAEP
DMSTPVEPPR VMKDYNALAM ESLQNGNEPK RVDTLALLPT PDSCPIIPIH PPASANGVPS
SHRGISRKHV KIAYNFHRNV FEMEVMGRNG AFMGADWLAP GQVRPLHSGD FIQIGGVRVR
FLLPDVPIGG TGSEATESPV PESNEAARSR PEGGSAKIES EGEADNSGGE DSARNKEAGK
VKVKKLTVTV SGQKPSTEES QTPQPARRRG PGRPPKDGIM SKRERAEIAR EQKLAARREA
NGGVTPPPTT KSKASKSGKD GEAEDQPAVK PEKRKYTKRK RPDSAPGDSV VQSIEGGDGN
IAPGQEEPIK PAPVKKRKPS RSPSPDYPPE SFYTPKELAK PPYNYAVLIY DALSESPTPM
TLKQIYRALK LKYPYFRFRC ETEGWTSSVR HNLNGNNHLF MHAERDGKGW SWKLIPGASV
DKEKKRRPSP PPQDITNHNN QPFLPPSAVP QYTIPHGMPA QHPPPQYPYQ PITQHPTPMA
PPPLPPPPPA RRANPFPFTL PHLPQTVLPE HDLPRPFSLL RSPVYSSPYS STPPPPHFPH
PRHRRAPPQP PPQRRQPPPS APVAPPPQNY NAPSIIKFQS QPYNAVPHPS QPPPQAPPPP
PPAVPIHPMP PAPPPPPQNT SPISSLSLIN QDPAFLSRAN QAIDNFEAVL MEDYEDQEYI
KKVLRSARDR VLNGAKESSF PGGEPKDEAV IINALRGIIG QLTGDQSQAG IP
//