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Database: UniProt
Entry: E9CZW0_COCPS
LinkDB: E9CZW0_COCPS
Original site: E9CZW0_COCPS 
ID   E9CZW0_COCPS            Unreviewed;       599 AA.
AC   E9CZW0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   08-MAY-2019, entry version 26.
DE   SubName: Full=Tripeptidyl peptidase SED3 {ECO:0000313|EMBL:EFW20213.1};
GN   ORFNames=CPSG_03388 {ECO:0000313|EMBL:EFW20213.1};
OS   Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Coccidioides.
OX   NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN   [1] {ECO:0000313|Proteomes:UP000002497}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
RN   [2] {ECO:0000313|Proteomes:UP000002497}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J.,
RA   Gardner M.J., Kirkland T.N., Taylor J.W., Young S.K., Zeng Q.,
RA   Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chapman S.B.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E., Heiman D., Howarth C., Jen D., Larson L.,
RA   Mehta T., Neiman D., Park D., Pearson M., Richards J., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA   White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Coccidioides posadasii strain Silveira.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
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DR   EMBL; GL636489; EFW20213.1; -; Genomic_DNA.
DR   EnsemblFungi; EFW20213; EFW20213; CPSG_03388.
DR   Proteomes; UP000002497; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002497};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    599       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003237435.
FT   DOMAIN      212    599       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    288    288       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    292    292       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    502    502       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       544    544       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       545    545       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       577    577       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       579    579       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   599 AA;  66457 MW;  2D76C884C8606F88 CRC64;
     MVALNFRAIG ALLSLPFLVN GAPASHLSQS FQVVEHLDRI PETWQRGEPP SPNAPLRLHL
     AMQNDVLDQF EQRVLDISTP GNEHYGEHMT RDEVQAFLQP PSYTSDAVLA WLLEGGVSEK
     SIQLDSDWLH FTIPVKKAEE LFNTQFYYYH NKVNKARVLR TLEYSVPKII APYVHMIQPT
     TKFSEPRPQF NSVFEQHGLP RVRNARVDCN RTITPDCLRD LYKLGDFRAK VDSRNKLGIS
     GYLEQFARYD DFARFLDLYA PQLKGTTFDV VSINGGRNDQ NSSLNSIEAS LDVDYAIGLS
     GAKSVYYTTA GRGPLIPDLD QPHANESSNE PYLDQLHYLL SLPDDQLPSV LSTSYGENEQ
     SVPKKYTDMT CNLFARLGAR GVSVIFSSGD TGVGCACQTN DGKNTTRFLP VFPAACPFVT
     SVGATHNINP ERAIFFSSGG FSDRYRRPWY QEHAVGHYLR RLGSRWEGLY NPAGRGFPDV
     AAQGLNFSVV DHDRVIGVSG TSASAPVFAA IVANLNSIRQ EKGKPVLGFL NPFLYTVGRF
     GFTDIVHGGS TGCTGKDMYS GLPTPFVPYA SWNATKGWDP VTGLGTPNFE VLKKLVTIF
//
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