ID E9D8I9_COCPS Unreviewed; 709 AA.
AC E9D8I9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=DUF726 domain-containing protein {ECO:0000313|EMBL:EFW17698.1};
GN ORFNames=CPSG_06141 {ECO:0000313|EMBL:EFW17698.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
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DR EMBL; GL636494; EFW17698.1; -; Genomic_DNA.
DR AlphaFoldDB; E9D8I9; -.
DR VEuPathDB; FungiDB:CPSG_06141; -.
DR VEuPathDB; FungiDB:D8B26_000367; -.
DR eggNOG; KOG2385; Eukaryota.
DR HOGENOM; CLU_007407_1_0_1; -.
DR OMA; DWLLRFI; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF3; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 261..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 78067 MW; F48A5707E5B19E11 CRC64;
MATQNPWRGG PRATAQEEAQ PMKAEEDLNQ VLSTSQRREL IALVKCIMDE MQEILCHPSE
HYIDPTPDAP DRSNAQNPEA LPPRQETQQL QSSRAGTSIS KAQVKIELEA FDYFKSWKQS
VLGRLGEAIE TSGSPEKQPP RPMDPIEPEP APVDPKDRAS ISNRTEYPDP FNPHLKKLPM
ETRLLITNSF LLLLLSLKSY NAHSRALLLK LSTNLGISAE HLAENEIKVA QGLLKAAKEM
SASDEAKARA DESKASRRWK IGLASVAGAV LVGMTGGLAA PLVAGGVGMI MGTLGLGGTV
AAGYLGAVAG SGVVIGSIFG AFGARMTGRM MEKYAREVRD FAFLPLRAPP AKSENETVPS
TIDTRLRVTI GITGWLTEPY DLVNPWRVLG KDSDVFALRW ELQALLMLGN AMESLVRRFA
LTFAAQQLLN KTILAPFSGP LMIPMVVLKL SHLVDNPFNV AKTRAEKGGE ILADALINKA
QGERPVTLIG YSMGARVIYA CLLSLAKRRA FGMVESAILI GSPTPSDTAQ WRLIRTVVSG
RLVNVYSKND LMLRFLYRSQ SVQMNVAGIQ PIENVPELEN LDASKMVPGH LRYPLLVGAI
LEKIGFDHLD QDELRRQADR LRALAAEDER LVDQAQREEQ QHEPAQVFVD SNALDRDQKC
PEEPPISNAE IQNLEDEITR RTEDSLVEIH MQSIQLEDRE GQQNHFLPG
//
