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Database: UniProt
Entry: E9DJG9_COCPS
LinkDB: E9DJG9_COCPS
Original site: E9DJG9_COCPS 
ID   E9DJG9_COCPS            Unreviewed;      1040 AA.
AC   E9DJG9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE            EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN   ORFNames=CPSG_09968 {ECO:0000313|EMBL:EFW13422.1};
OS   Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN   [1] {ECO:0000313|Proteomes:UP000002497}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
RN   [2] {ECO:0000313|Proteomes:UP000002497}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA   Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA   Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA   Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA   Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA   Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Coccidioides posadasii strain Silveira.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC         Evidence={ECO:0000256|RuleBase:RU000417};
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR   EMBL; GL636516; EFW13422.1; -; Genomic_DNA.
DR   STRING; 443226.E9DJG9; -.
DR   VEuPathDB; FungiDB:CPSG_09968; -.
DR   VEuPathDB; FungiDB:D8B26_001459; -.
DR   eggNOG; ENOG502R6QN; Eukaryota.
DR   HOGENOM; CLU_003836_1_0_1; -.
DR   OMA; ENDSASC; -.
DR   Proteomes; UP000002497; Unassembled WGS sequence.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd04370; BAH; 1.
DR   Gene3D; 2.30.30.490; -; 1.
DR   Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR00675; dcm; 1.
DR   PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR10629:SF54; DNA METHYLTRANSFERASE DIM-2; 1.
DR   Pfam; PF00145; DNA_methylase; 1.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000256|RuleBase:RU000417};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000256|RuleBase:RU000417}.
FT   ACT_SITE        618
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   1040 AA;  117693 MW;  87BE658163FCFE69 CRC64;
     MSSLEWISSP EPINEEKDQQ TVSPPNCDDF VGVVIPRQTL NTSAFEGFEP PLPKSTERDA
     IDTLLRDFSS YEIYDGSEFL SVQLDDFSIY KDRATNERNY GLIALNDVAK VAGSPVFFFD
     GIVRPEVVDD PVFYLERISF MTVSIGGYED LERHGVGNDV WIQSTYCNTR GQIWYRLGKP
     AREYAPYHHT FLWVANLAKH FVDYLKENRN VALSAFKSHF REWLWEHHHL DSTFRGWLEE
     FGGSDFRQAI VAHAPFLRGQ ALGLDSEYEE HFLWDEIGLS STPAVPKQPS RAKYTVVTPY
     IYKCFKDMPW GQYLQIVNLD STMAARHQQL VHRMGFVPRK RRVVTGSKAP IEPGDVVAIN
     RDNQTSWKGD DDLWQTYHSG DETFRTLHKG DFECQCSKSQ DRKYNVGDTV LVETSDVLEP
     VEIVEVSGDE VKVRVLLRRS RDFNDDSCRP NELVYTGHFR HIHLEEIRRR CHIRFFSEEQ
     RDKGGIPAPY NRDGNGSAFY ITCEESAQGL RPMTRPASFC DGFDPLEAKR KLRALNLFCG
     GGTFDRGLEE GTAIRSEWAV EWDLPPMLTY RANHTNPEDV KLFRGSVDDF LAVAIRGQGS
     DLVAKLGQVE FISAGSPCQG YSLANSRKGN KVSLRNSSMI ASVAAYVDFY RPQYAILENV
     PAMASKTHER NPLSQLICAF VGLGYQLRLM HLDAWSYGAP QSRSRLFLLI AAPGLQLPEH
     PALTHSHPMG TTIRSLGEAP NGLPFGERRW EVPIFKFVSA YEGTKDLPDL DRAKVASIPW
     PDHRTSRNES NMTQVIIDQV PKHPRKSGFS EAMTKGFLNF DPFPGDIKRR NPPSRAWSRV
     DPNFLIPTIT TAISPHCKFT GRWLHWREDR LLTIMEARRA QGYPDSEVLV GRAAHQWKIV
     GNSVARQVAL ALGLSIREAT LCNPPLPPYG ETEEIIETCL NKKKRKRRVS EIVVNTSTAT
     VVTTTTTTRY RLEQDLSIED TSTGISTLSL GERTGTPFND ISNPLQVSLS PLSKPWNPIL
     KKVKSVQDEG SSSEDPILID
//
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