ID E9DJG9_COCPS Unreviewed; 1040 AA.
AC E9DJG9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN ORFNames=CPSG_09968 {ECO:0000313|EMBL:EFW13422.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|RuleBase:RU000417};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; GL636516; EFW13422.1; -; Genomic_DNA.
DR STRING; 443226.E9DJG9; -.
DR VEuPathDB; FungiDB:CPSG_09968; -.
DR VEuPathDB; FungiDB:D8B26_001459; -.
DR eggNOG; ENOG502R6QN; Eukaryota.
DR HOGENOM; CLU_003836_1_0_1; -.
DR OMA; ENDSASC; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd04370; BAH; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF54; DNA METHYLTRANSFERASE DIM-2; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW ECO:0000256|RuleBase:RU000417};
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW ECO:0000256|RuleBase:RU000417}.
FT ACT_SITE 618
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 1040 AA; 117693 MW; 87BE658163FCFE69 CRC64;
MSSLEWISSP EPINEEKDQQ TVSPPNCDDF VGVVIPRQTL NTSAFEGFEP PLPKSTERDA
IDTLLRDFSS YEIYDGSEFL SVQLDDFSIY KDRATNERNY GLIALNDVAK VAGSPVFFFD
GIVRPEVVDD PVFYLERISF MTVSIGGYED LERHGVGNDV WIQSTYCNTR GQIWYRLGKP
AREYAPYHHT FLWVANLAKH FVDYLKENRN VALSAFKSHF REWLWEHHHL DSTFRGWLEE
FGGSDFRQAI VAHAPFLRGQ ALGLDSEYEE HFLWDEIGLS STPAVPKQPS RAKYTVVTPY
IYKCFKDMPW GQYLQIVNLD STMAARHQQL VHRMGFVPRK RRVVTGSKAP IEPGDVVAIN
RDNQTSWKGD DDLWQTYHSG DETFRTLHKG DFECQCSKSQ DRKYNVGDTV LVETSDVLEP
VEIVEVSGDE VKVRVLLRRS RDFNDDSCRP NELVYTGHFR HIHLEEIRRR CHIRFFSEEQ
RDKGGIPAPY NRDGNGSAFY ITCEESAQGL RPMTRPASFC DGFDPLEAKR KLRALNLFCG
GGTFDRGLEE GTAIRSEWAV EWDLPPMLTY RANHTNPEDV KLFRGSVDDF LAVAIRGQGS
DLVAKLGQVE FISAGSPCQG YSLANSRKGN KVSLRNSSMI ASVAAYVDFY RPQYAILENV
PAMASKTHER NPLSQLICAF VGLGYQLRLM HLDAWSYGAP QSRSRLFLLI AAPGLQLPEH
PALTHSHPMG TTIRSLGEAP NGLPFGERRW EVPIFKFVSA YEGTKDLPDL DRAKVASIPW
PDHRTSRNES NMTQVIIDQV PKHPRKSGFS EAMTKGFLNF DPFPGDIKRR NPPSRAWSRV
DPNFLIPTIT TAISPHCKFT GRWLHWREDR LLTIMEARRA QGYPDSEVLV GRAAHQWKIV
GNSVARQVAL ALGLSIREAT LCNPPLPPYG ETEEIIETCL NKKKRKRRVS EIVVNTSTAT
VVTTTTTTRY RLEQDLSIED TSTGISTLSL GERTGTPFND ISNPLQVSLS PLSKPWNPIL
KKVKSVQDEG SSSEDPILID
//