ID E9DJU4_COCPS Unreviewed; 2073 AA.
AC E9DJU4;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=20S cyclosome subunit APC1/BimE {ECO:0000313|EMBL:EFW13282.1};
GN ORFNames=CPSG_10093 {ECO:0000313|EMBL:EFW13282.1};
OS Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=443226 {ECO:0000313|Proteomes:UP000002497};
RN [1] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
RN [2] {ECO:0000313|Proteomes:UP000002497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RMSCC 757 / Silveira {ECO:0000313|Proteomes:UP000002497};
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Coccidioides posadasii strain Silveira.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the APC1 family.
CC {ECO:0000256|ARBA:ARBA00010547}.
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DR EMBL; GL636525; EFW13282.1; -; Genomic_DNA.
DR STRING; 443226.E9DJU4; -.
DR VEuPathDB; FungiDB:CPSG_10093; -.
DR VEuPathDB; FungiDB:D8B26_005425; -.
DR eggNOG; KOG1858; Eukaryota.
DR HOGENOM; CLU_000746_0_0_1; -.
DR OMA; RNSVRNC; -.
DR Proteomes; UP000002497; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR024990; Apc1.
DR InterPro; IPR048971; Apc1_3rd.
DR InterPro; IPR049255; Apc1_N.
DR InterPro; IPR011989; ARM-like.
DR PANTHER; PTHR12827:SF3; ANAPHASE-PROMOTING COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR12827; MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER; 1.
DR Pfam; PF12859; ANAPC1; 1.
DR Pfam; PF21282; APC1_3rd; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002497};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 31..820
FT /note="Anaphase-promoting complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12859"
FT DOMAIN 1789..1869
FT /note="Anaphase-promoting complex subunit 1 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF21282"
SQ SEQUENCE 2073 AA; 227964 MW; D5063B08F057D926 CRC64;
MAAIRSLGLH EPSAIPYLVG ESIILQHTPD DDRFIWKTCH YEDENNTPVE EELFLTDHCV
VWSRGGVVVR SFGFDVENEK VVHALFAYFP DGERTNDTKK GSGDVPGSGT TARGPVSRTD
NLRGLSGRQG KQVTIEEKLN IDGIAGLSIV EGSVKRPVAR ALVVVLQSQI HIFFLSGDTH
VIPLPFEVGS VWATPCGLLF QRKASEDNTP VPLVPPNSFV SSQVLHGKPR TSGSFTQSAR
SSARFSLTLS PSHPAKWNLK PEPEASQPRT FSLLDPHSEM GLVAVSPGAQ HARAAKTLEA
LSASEEILYV SFTNEFPELA STAQVNGPLI LVVTLNETAG VYTIWTAQQR DKGSAIRHSQ
KRRSSSGTVA KRRSSYFDVA AGATTPGGRG SNALRESFSM LSQGRSVSHP LNNQNTDTRP
EDAEDLASQL GHDFNDIGVS WKASRRVSSL LARSDLGANH DRNTFSDLVT GNQSNIPLSR
KRDSFAGSSR ASLGYRRRSS LPPGNTSVFS AASSFLDAPV DKFLDGLTKG GNFEGFDSMG
LGESVSGLPK EVILSKVGSY SSGFSSVQGI PPFEKGRKFE VFTLSSFYET SQNDPDSTPL
AVCILNRHSR NLLVLNLQVR RAQRSSLSSK KSKAKATQGN LLHTVQLKDV RQGSNVIDCR
KLVDGSISRM IVLSTTMDGR GELTLQAPWS TLVKIDLPSS MVLHDPSGIS FARSSFHPRE
AGLRRVLDTS DINLCGLDHP SNRGKIDITD SQNRRHRLQI QLEPRNLLVK RALSVCRFAL
RQSEKAGDGI LVCWWEVLRW LRARNEGEND LEWTAFVVTL FSMAVYFIDG NFSKPIVKPK
RKRGTLLRSS SGSSVDLDSW DAMLERQSGS SGVGPSWMMT PAWGWILEEQ ERREDVFRSE
HQPSLFLTCG PASRKNGYIL RCASLAREFI SSPQGEAASG AEGYLPTAIS QDPGTRKTAL
GAILVALHLF REELKLSTID ADLSNCDSGL MVPVLAQIGG WLGWSSWTWE EHAYYGTESA
SMESWLFEQS QISRLDVPEE PFPPPSLFQF VENFLQNKPS SFMTLIDMVS SSGAKQGSGK
IWEQALSLTP RTLAISGFFS EINLQSSTVE KTALLLRWGL TSSVIDTLPI GISAPLHEAI
IRCGGNATPR CGPSLLKLVD RNDLSLTMTN EHLTPTMPRL QVLQSHDALR DVHHIGCSVY
DGSGVNSFEA STEADRLSIT KLIFREDRRY FEAVKILNQT RAPVAECLQE PDWSEADLLE
AQKELVQLVT LRTLSIPSGR GLMSFSSRVP LSTEKLPIPS FSLQCVVKPS NITISAERTA
FTEEKVCWAF FHNGASTGLA ISKAAKGIDT SWILYNKPGE LTNRHAGFLL ALGLNGHLKY
LAKWVAFKYL TPKHTMTSVG LLLGLSASYL GTMDTLITRL LSVHITRMLP LGAAELNLSP
LTQTTGIMGI GLLYCNSQHR RMSEIMLSEI ENMEPEDTSM SQEMLRDEGY RLAAGLALGF
INLAKGKDLG GLRDMRIIER LLALAVGTKK VDMVHILDKA TAGATVALAI ISMKSNDKSL
AKQIDIPDTI AQFDYVRPDI FLLRTLARHL IMWDSIKPSH DWVQKSLPKP YQRKSRLITV
RRLSTDDMPL FNIIAGICFA VGLRYAGSAS TEARDLLVAF LDQFIRLCRL PAINYDAKLT
RNSVRNCQDT VALSAALVMA GTGDVTVFRR LRSLHGRVDP DTPYGSHMAA HMAIGVLFLG
GGTYTVGTSD LAVASLLCAF YPLFPTTVLD NKCHLQAFRH LWVLAAEPRC LIPRDLETGR
AMQIPVSLTL NSGETTTAMA PCLLPELATI ASVKVQSPDY WNLTLDFTTN EILRDKFRHG
NQSIYLKRRT TYNAEKSAFA ATMSALSELQ DVPVSSSKLM GATGNPVTPA LYAHGKSTVE
VRIPVRHLWE WIFNLGAFRH LDMSEKTLVL PPNPFDQPLK PSPGREDIVL PSWIRPTVVE
ARLALDRTVR NMIAAAAGRG AGADVIRDRL WQLRLLFAWV EGIERAAKAK DGGSEDDEDR
EEKGLWLRKD VIEDIKWKIW AIQAGDEGVL GKG
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