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Database: UniProt
Entry: E9DS88_METAQ
LinkDB: E9DS88_METAQ
Original site: E9DS88_METAQ 
ID   E9DS88_METAQ            Unreviewed;       962 AA.
AC   E9DS88;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE            EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE   AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN   ORFNames=MAC_00486 {ECO:0000313|EMBL:EFY93248.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY93248.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY93248.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC         tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC         COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001372};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; GL698471; EFY93248.1; -; Genomic_DNA.
DR   RefSeq; XP_007806826.1; XM_007808635.1.
DR   AlphaFoldDB; E9DS88; -.
DR   STRING; 655827.E9DS88; -.
DR   GeneID; 19244797; -.
DR   KEGG; maw:MAC_00486; -.
DR   eggNOG; KOG0435; Eukaryota.
DR   HOGENOM; CLU_004427_0_0_1; -.
DR   InParanoid; E9DS88; -.
DR   OMA; TFMVLAP; -.
DR   OrthoDB; 2876972at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00812; LeuRS_core; 1.
DR   Gene3D; 3.10.20.590; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR002302; Leu-tRNA-ligase.
DR   InterPro; IPR025709; Leu_tRNA-synth_edit.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00396; leuS_bact; 1.
DR   PANTHER; PTHR43740:SF2; LEUCINE--TRNA LIGASE, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 2.
DR   Pfam; PF13603; tRNA-synt_1_2; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR00985; TRNASYNTHLEU.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT   DOMAIN          91..224
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          276..469
FT                   /note="Leucyl-tRNA synthetase editing"
FT                   /evidence="ECO:0000259|Pfam:PF13603"
FT   DOMAIN          485..650
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          689..730
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          786..907
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
SQ   SEQUENCE   962 AA;  106714 MW;  CCB3F2480DDEB138 CRC64;
     MQLVYAKQIG CKGACPALRV ASRWPPGISR PSLIQLPVAP AAASLRRWYA VNLTSLDSKW
     RKIWSEADQA GAKQPNSPRT GDRKTNYVLP MFPYPSGSLH LGHLRVYSIA DTVARYHRLK
     GDDVLLPMGW DAFGLPAENA ALERGIDPGV WTRRNIKKMK EQLGFMNGSW DWSRELTACD
     PEFYKHTQKL FLMLHERGLA YQAEAEVNYD PVDKTVLANE QVDANGCSWR SGAKVEKRKL
     KQWFFRTSEY REALLRDLDE LAKNNAWPDR VISQQKNWLG KSTGALVKFP IMAVGGVNVG
     NAIEVFTTRP DTLFGVQYVA LAASHPVVAK LAKRDAELQA FLDTLPGLPP DSKVGYLLPH
     LRAINPLAYH DETPDATKAS LPIYVAPYVL GDYGEGAVMG VPGHDLRDHS FWKTHQEDQP
     VRIVLTASED ESTTTLPMSE PYLEHGVMTH HSGAFKGKRS VEAGQIMVRM LEAANLAKSV
     EKWRLRDWLI SRQRYWGTPI PIIHCASCGA VPVPDEDLPV KLPNVEKHWA KGKTGNALES
     SPDFVNTSCP KCKGPACRDT DTMDTFVDSS WYFARFIDPH NTQQLFSPEA SKILPVDTYI
     GGIEHAILHL LYARFVYKFL ASTSLMPEYT DETASSAEPF KRLITQGMVH GRTFIDPENG
     VFLKPDEVDL SDPSSPKIIA TGVPAKVAFE KMSKSKHNGV DPSECIAKYG ADATRAHIIF
     QAPVGYILNW DEAKISGVTR WLQRLHDQVV AVAAADESRP AKALLEGKFG SVGSMSSEEL
     TQWDADTALW REVQHTIASV TQSYDEVYSL NTIVSDLMRL TNTLAGSQAN EVIKKHACSV
     LSRLVAPITP AFADECWSVL HPSKGLIFNA STFPSQDGTL DSAMLQPRQR SCAVQINGKM
     RGVVDIPTPP TDLQGDALKD WVVEEILKTE QGKERFGVGK YDLAKAKRVI AVRGGKVMNF
     VL
//
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