ID   E9DTL7_METAQ            Unreviewed;       696 AA.
AC   E9DTL7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|ARBA:ARBA00044146};
GN   ORFNames=MAC_00855 {ECO:0000313|EMBL:EFY93072.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY93072.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY93072.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024149};
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; GL698472; EFY93072.1; -; Genomic_DNA.
DR   RefSeq; XP_007807195.1; XM_007809004.1.
DR   AlphaFoldDB; E9DTL7; -.
DR   STRING; 655827.E9DTL7; -.
DR   GeneID; 19245166; -.
DR   KEGG; maw:MAC_00855; -.
DR   eggNOG; KOG2454; Eukaryota.
DR   HOGENOM; CLU_005391_1_0_1; -.
DR   InParanoid; E9DTL7; -.
DR   OMA; ILMRGTF; -.
DR   OrthoDB; 5743at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07098; ALDH_F15-22; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT   DOMAIN          175..639
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        410
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   696 AA;  75496 MW;  2BCB0223291684D7 CRC64;
     MSSSWWSNFP PVNPTPKPGR QSKPDMPLCK HQLLKSSWLL RNRQKSRAVA SREYFSSALN
     QWRPSSWSGW RRGGTTSATT RLRDLTFRTD LSKAPVLLFL PTQLLTVPDI HRTTTLQIGC
     AITAILISSI VTRLLVRAHA NSTPRPIRYR VPPAKLPETR TTVEQTSIRI PGTSAIQCYA
     PATGQFLGLV NPSTPDGIDR AVAAASAAQR TWRQTSFRER RAVLRSLMQY VLDNAEDICR
     VAGLDSGKTM VDAQLGEILV TVERIQWTLL HGEKALRPSR RPTNLLMAYK RNTVHYEPLG
     VVSALVSWNY PFHNMMGPVI SALFAGNGIV VKVSEQTAWS SAHFAEIARG ALAAHGHDAG
     LVQTVACWPQ TAGHLTSHPG ISHVTFIGSQ SVAHHVAASA ARSLTPVVAE LGGKDPFVVL
     DSAARDLARI AEVVLRGTFQ AAGQNCIGIE RVIAAGRVYD RLVDMLAPRV RALRLGPDAD
     VGAMISDASF DRLEELIAEA VSQGARLLAG GKRYDHPDYP SGHYFQPTLL VDVTTDMRIA
     QHECFAPVLT MLRAKSSSAE DMLAVANAPN FGLGASVHGS ERDPAMGPIV RGLKAGMVAV
     NDFAAYYAVQ LPFGGVAGSG YGRFAGEEGL RGLCNVKSVC EDRFWWMGIR TGIPPPVQYP
     VPSQKKGWAF TQGVVEVGYG DGPRKIKGLG KILGNM
//