ID E9DWC5_METAQ Unreviewed; 718 AA.
AC E9DWC5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=MAC_01923 {ECO:0000313|EMBL:EFY91975.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY91975.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY91975.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
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DR EMBL; GL698478; EFY91975.1; -; Genomic_DNA.
DR RefSeq; XP_007808263.1; XM_007810072.1.
DR AlphaFoldDB; E9DWC5; -.
DR STRING; 655827.E9DWC5; -.
DR GeneID; 19246234; -.
DR KEGG; maw:MAC_01923; -.
DR eggNOG; KOG2747; Eukaryota.
DR HOGENOM; CLU_011815_0_0_1; -.
DR InParanoid; E9DWC5; -.
DR OrthoDB; 118560at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF180; HISTONE ACETYLTRANSFERASE SAS2; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFY91975.1}.
FT DOMAIN 270..636
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 1..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..182
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..265
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 530
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 718 AA; 77427 MW; 9CAD45E79BC4B350 CRC64;
MPQKRRRLEE PAQPALAEQS SSLRRTTRQT PVLPPLPPTS AAVAKVAQAP AVADPTAMAT
TTVTATASAS APAPATATGA NGPGSAVSGR PQLQPTGPAT TASTATTTTV SNAIATSQTP
VPIPTPLGSG QQPNRSRERP QSTIPPPPFP PTYSPPVKTP VPVPVVTPIS PPSIPRRPLP
SLGSNPPAGR SMSAVSVTDN ARPSDLVAPE ISYHVPQPAV PGRVQSSLLR PHGPSALPPR
LDRRPAPPVV TPVPPPKPPT LPVNDRGPPR ADRNIDKVVL GDLCFRTWYP SYYGKEILGD
TSGNSRNGGG SKDGSNEASS KASKRDKDNQ PMLERLYVCP SCFKYAKELV AWRGHVRVCE
RKAFIPGKKI YRHPRGRRKV LVAFEGKGPG PKRRRGDSGI RYTEEIVHDE GEWSIWEVDG
EKHGLFCQNL SLFAKLFLDN KSVFFDVTGF NYFLLVYTPP ASPVAPETEP IQTRPPQVCG
FFSKEKMSWD NNNLACILVF PPWQRKGLGA LLMGASYEIS RREGILGGPE KPISDLGKKG
YKRFWSGEIA RWLLSLESTA PQPQPQSPQV AGGPVITQEL IVDVNDCSRD TWIAAEDCLG
VLRDMGVLED AGMGFGKPEK KADAAAEEDE SRELLPEGGD GAAHKQQDLV SRSAEEKRSL
SVKVVPRVRI DKEVVRRYVA THRISLERTC DPDGFVQGYA MKVDSSGNDG DKTGVETA
//
