ID E9DZD0_METAQ Unreviewed; 1019 AA.
AC E9DZD0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=MAC_02978 {ECO:0000313|EMBL:EFY90862.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY90862.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY90862.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR EMBL; GL698486; EFY90862.1; -; Genomic_DNA.
DR RefSeq; XP_007809318.1; XM_007811127.1.
DR AlphaFoldDB; E9DZD0; -.
DR STRING; 655827.E9DZD0; -.
DR GeneID; 19247289; -.
DR KEGG; maw:MAC_02978; -.
DR eggNOG; KOG0478; Eukaryota.
DR HOGENOM; CLU_000995_7_1_1; -.
DR InParanoid; E9DZD0; -.
DR OMA; NRCSFAD; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR CDD; cd17755; MCM4; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008047; MCM_4.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF66; DNA REPLICATION LICENSING FACTOR MCM4; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF21128; MCM4_WHD; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01660; MCMPROTEIN4.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Cell cycle {ECO:0000313|EMBL:EFY90862.1};
KW Cell division {ECO:0000313|EMBL:EFY90862.1};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT DOMAIN 599..807
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 112032 MW; 2E54D085E0C8A6A0 CRC64;
MSSPSQRRQR SSQSATPRRS TRQSEANTPR NAPSQLASSP IFFQSSSPGP VAGQEHGENG
DVSSPLRQMT DSQSTQAHAA TPSSPLRQMS ESQTPRDDPQ RTPRASGNFA GESSPIRYEP
SSSPGRSLGL RSELRSESSG LFVGSERGSS AAYRRGDINS DALRTPRAPR RIILDDTGRV
VQEGQTPGSD AASFANRDPN TSEADVLGGQ GQSLIWGTTV SIDDTFAAFK DFLRHFTQKY
RMYRDGFSDA EVQAAPDAES KPYLEAMENM LLLGTTRLYL DISDLNLYPP TRKLWYQIQA
YPQEIVPIMD QSVHDLMVEL ARADSLKNRQ SQSSAGQHDT QNSTQSSEPV FPSSDRPDDP
ATPRPPQDQP SLEDQVSANL YVVRPFGLDK TINLRDLNPS DMDRLISIKG LVIRTTPVIP
DMKDAFFRCN VCNHSVNVSL DRGKIREPTE CPRQICNSKN SMQIVHNRCS FEDKQVIKLQ
ETPDAVPAGQ TPHSVSVCVY NELVDFCKAG DRVQLTGIFR VSPVRVNPRQ RAVKSVYKTY
VDVLHVQKVD KKRMGADPTT LGIEGEEDAD NGANGLEQTR VITPEEEAKI RETAARNDIY
ELLSRSLAPS IYEMDDVKKG ILLQLFGGTN KTFQKGGSPK YRGDINILLC GDPSTSKSQM
LSYVHKIAPR GVYTSGKGSS AVGLTAYVTR DPETKQLVLE SGALVLSDGG VCCIDEFDKM
SDATRSVLHE VMEQQTVSVA KAGIITTLNA RTSILASANP IGSRYNPDLS VPQNIDLPPT
LLSRFDLVYL ILDRVDEKAD KRLAKHLLSL YLEDKPHSAP TSDDILPVEF LTLYISYARA
QVQPVISREA GEELVSAYIA MRALGQDVRA AEKRITATTR QLESMIRLSE AHAKMRLSNT
VTKEDVREAN RLIQSALKTA ATDSQGRIDM SLLTEGTSAA DRKRRGELRD AILKLLDDMT
AGGNSVRWGD VSKRLADGAS IPVEAAEFNE VMRALETENL ILISGEGARR SVRRVTAVV
//
