ID E9E0I7_METAQ Unreviewed; 1577 AA.
AC E9E0I7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=General negative regulator of transcription subunit 4 {ECO:0000313|EMBL:EFY90607.1};
GN ORFNames=MAC_03385 {ECO:0000313|EMBL:EFY90607.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY90607.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY90607.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
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DR EMBL; GL698489; EFY90607.1; -; Genomic_DNA.
DR RefSeq; XP_007809725.1; XM_007811534.1.
DR STRING; 655827.E9E0I7; -.
DR GeneID; 19247696; -.
DR KEGG; maw:MAC_03385; -.
DR eggNOG; KOG2068; Eukaryota.
DR HOGENOM; CLU_001793_0_0_1; -.
DR InParanoid; E9E0I7; -.
DR OMA; CLITPRG; -.
DR OrthoDB; 1748at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16618; mRING-HC-C4C4_CNOT4; 1.
DR CDD; cd12438; RRM_CNOT4; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034261; CNOT4_RRM.
DR InterPro; IPR039780; Mot2.
DR InterPro; IPR039515; NOT4_mRING-HC-C4C4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12603; CCR4-NOT TRANSCRIPTION COMPLEX RELATED; 1.
DR PANTHER; PTHR12603:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF14570; zf-RING_4; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 111..197
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 77..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1178..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1577 AA; 167743 MW; BFC923260510E86F CRC64;
MAPQDSFIEE EEDVCPLCIE EFDLSDRNFR PCPCGYQNNM NGLCPACRRP YDEKTIEWKV
VTQEEVAEFR ANIQKNQKKR AQEQRQKEVQ KREAEKENRK NLVGVRVVQK NLVYITGLAP
TVREDELLKT LRKPEFFGQY GNIQKISISN RKSPDGQHHS LGIYVTFEKP EEATKCIIAV
HGSQNGDRIL KAQHGTTKYC SAWLKNEKCN NPGCMFLHEQ GDEEDSYTRQ DLSSMNSIHT
QRPLPGGGGG SSRAVSRQHI SHPTPPPPAS QPMVRTTSRD GSDNGVDSSA LPSSANWARN
PQRSRRGSYA TSGAASSPAI SMSLPATTEA TQEAIDDADA SSAQQPVANK GKQPHGTQAQ
TSTPSQEKKE QRSSKTTDSA LVALLKTLEV CKLPVFTTAN ASDDTHPPMF DIRGGEKRRA
MREDEESRID QEDQTEAQAP SEGEPETGGS LALGGEPEDR ELGRDVHGFD QRQSSTQPPI
QRGSTDGLYG APSSGSGFPQ GSSNIGRVMT PQQLASLRLQ AGYTDQMPPG ISAQNPFQNP
GHNRQSSRFS FANDAGNSTT NIKLAANPRI MAQQSSMMPS SFQSQSSNQF YATSMPGPPP
GLKSTGTPPS MFGQGFGTGS GFGGAHKDSS GDLLQTLIGR NRGGSTQPQD VGKPPASGLL
ASLYGNHPGA FQDFGSKQKK KGKKHRHANT SSSGGSGLVD LADPSILQAR MQHQSQSNAG
VAGQQGLFGG GQSQGICVVA ASIPYTGSHY GATPPEGSIF GQNITILSIL SNSAFPFIVP
LWKTMMEATQ PVLTVLQDEL LSLDEATSSV DALVSDEPQG VYAGSGFGFD MGMTRSAPPG
FAIHPEMVNA PMSAMASPAL SQHRQAEAVP TLSTAPPPGL EHGTVTPVQT PRKVTAPGLE
ATSNSRPSTS EARVSKHMTS QPQFEQQSVS SPLGDEDFPA LGSSQSIKAR TQSPATPVVP
TPKPTPAAKK RANGMVDKAA SSHDHPASMV SDSIKNRPST ISIQPPSDKS VASHDLQGTD
KPLEDSSTFP PLPTATASFP SPVHRSGTRT LRLMPTPRAT ESPALPSPVQ SVASKAVSIS
HRPDTPGSEM ISDTASIMSA SISASRAGSP PPSKVGSAAV RTTTKSQQRK QRKEALKQET
RIIAEASKPE PEEHAPVIGR KKKQKKEKPA KATVSREIPT PPTASAPESS KTESEVPVQP
ESTNAKVVEE TDFKSRTMQK RAAKNKEKEM DMEKGQAKPT PTPASPPAVP SKLAEPGNSV
PAEPIESSDP ADRQQFGPAS VFQEIKSSLW TSALDKLLLL RPVSSSSPRA DLSQAANGAS
QSVYCKDYAC KCGEIQDDDL TALRAGKPVR KQFHVDGSRM LITPNGDCIR GLTPEQEDAF
LDLQAAIAST ADNPGAFVAP RHQPGSGAFS LIKGRAVPNG RPNIFPATAQ PQSQDPIGKL
QREDALSYIN QYVLPRLNLD AANMGFPKGA SPLRDAAAAS LNALAPYFYG PDAAAGVGIY
SAPDGARAMQ DFSSSGGAPA ADASKIGPAN GLGGISLMSV EDAEVRLAAS RKETEKLERG
LNAVIKRNRR LLLGGGN
//
