ID E9E5F9_METAQ Unreviewed; 1595 AA.
AC E9E5F9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Tuberin {ECO:0000313|EMBL:EFY88842.1};
GN ORFNames=MAC_05107 {ECO:0000313|EMBL:EFY88842.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY88842.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY88842.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
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DR EMBL; GL698506; EFY88842.1; -; Genomic_DNA.
DR RefSeq; XP_007811447.1; XM_007813256.1.
DR STRING; 655827.E9E5F9; -.
DR GeneID; 19249418; -.
DR KEGG; maw:MAC_05107; -.
DR eggNOG; KOG3687; Eukaryota.
DR HOGENOM; CLU_003828_0_0_1; -.
DR InParanoid; E9E5F9; -.
DR OMA; ATRFLMN; -.
DR OrthoDB; 20915at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT DOMAIN 1267..1508
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1502..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1553..1582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1508..1541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1553..1578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1595 AA; 177047 MW; 7C59AE18E780E10E CRC64;
MSPQPEDDPT SPDSTRPGGL ATVLRSLTNS KAIKAPPPPS NPSAALPRAE LINAIPTNSH
GLSTNHMDAF EQLKNGSPSE RISAANTLKY AITEYPLNPI LDIWYAAKDL IDPNNPPSTR
AAGWELLTEC AKHASSTDLE RKEYFQTLSA SANPEDFHLQ LAALVDLTSH GRVLDGFDYD
LLPLLTIWLQ NAYNAARIAR KNSHSGRGAG GSSRGKTAAL GEDKNFAQLF LFLLDVIKFS
FNTADEPAVT DLIDTILTIC MNTSQEDDLR SCINVLDAIV TFGSIPQSKL KDCVQVLSSI
YCLVPNLQKN SWHTIANLCK SHNGQATVRI MLDILRNLQP GINEKDSSRE IRGSLAVLQK
LLSKTTEKGY PPVPYALLVD GLSNTLKATK SLRVYAAALQ LINSLFDDGL GSIHRLIVDE
DWSTSLDVAA ECYRRVHEGT DGPQGIQAND ESLEAVVDRE LLKLVRRLDT VIKEKSRDFV
PRQTIVKFFT DVHNLLPDET AKTVLDYFQE FRCCSPSDLR WEENLNLVLK AFFSNRSRSS
DTRLRALQAM MDAYEIVNLV GDGAEQNFIP RMAKSILQNI AEEGDVLVLD AVMSLMVSVV
VSCDMELFDF VIDALRAIVV GDRLKSPISP SVLSATISPT MIDAPTPGLR QSQSPSHVVT
RGYVRMFLRL MNSHSCKSVK LYNALVGIAK TNHCETDARL TAMKLLFRLR ADWANRVFVT
DDLDNISLAT AMYRTDASFA KKQAEEAAQS LRLSRSDHGN QSRSSRGVSL SQSQHQERGH
PVRTPSGAKN ITARYQQLWR CPDPQALPEQ IPNLISPVLV SHSTATESSD ESEDADEAAS
NVLQQRKPSV LNMTNWLDAV LDILQGSEWE IYSFALVHLP SQLSNHAIFR DAIPQIQELR
RIICDQIRTN GFQEPPFASG LRRADVAICL FHSLTMILSY HEHFGKGDED EIVKTFILGI
GTWERTAKYC IHALSICCHE LPLSTSKSLV QMLNQMAASI TQPNVSVHIL EFLACLSRLH
NVYVNFREDE YRIVFAICFR YLEYARDKRQ LHRGSHNGEP NAAGMSGVAT GEPTQTGPPS
EELPQYVHAL AYHVILFWFL ALKLQDRATH VSWIVKKLFS DPDSTGQNAD EQALTSIDFM
QRVTYADVDE SCEDPYFTED RFGPIVKKQW IIGNSIVTVK QATVSGWAQI IKRQPSGTSA
YTIRETYAAP PPHQVENQVD VSREGQPTSN SILPSHVLVQ LMSPVPQSFE SARPIPLPDD
DAVDRAIRVF NRSSSVDSHK VGVIYIGEGQ ENEADILANV SGSSDYTEFL NNLGTLTKLK
GATFNTQGLD REYDSDGQYT FCWRDRVTEI VFHVTTQMPT NLERDPQCTL KKRHIGNDFV
NIIFNDSGKP FMFDTFPSQF NYVNIVITPA SRASFIATRT TDRPGATSGQ PFYRVQVLSK
PGFPEISPAS ETKMVSLNAL PGFIRLLALN ASVFSHVWNA REGGEHISSW SGRLREIKRL
RERYGPKTTT NLVPSPPPTS SSQNQPSESS RSSSSVRDSF SSLRRTSVAT FFTSTSEQTS
HRSSTLSTAP THDTEVGNAN GVNPLVESVD FSKWA
//
