ID   E9E7Y6_METAQ            Unreviewed;       543 AA.
AC   E9E7Y6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=U4/U6.U5 tri-snRNP-associated protein 2 {ECO:0000313|EMBL:EFY87993.1};
GN   ORFNames=MAC_05984 {ECO:0000313|EMBL:EFY87993.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY87993.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY87993.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; GL698518; EFY87993.1; -; Genomic_DNA.
DR   RefSeq; XP_007812324.1; XM_007814133.1.
DR   AlphaFoldDB; E9E7Y6; -.
DR   STRING; 655827.E9E7Y6; -.
DR   MEROPS; C19.972; -.
DR   GeneID; 19250295; -.
DR   KEGG; maw:MAC_05984; -.
DR   eggNOG; KOG2026; Eukaryota.
DR   HOGENOM; CLU_016848_2_1_1; -.
DR   InParanoid; E9E7Y6; -.
DR   OMA; NKFVAER; -.
DR   OrthoDB; 719409at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IEA:InterPro.
DR   CDD; cd02669; Peptidase_C19M; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR033809; USP39.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR21646:SF16; U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2; 1.
DR   PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00502}.
FT   DOMAIN          77..174
FT                   /note="UBP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50271"
FT   DOMAIN          199..527
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  62047 MW;  B9E94C96263EFA7D CRC64;
     MAKRHASEPL DELLGIASPA SKKSRTAEVE TPPHENGVPF AAPAQLDDGN NSSDNDDDLD
     EAVPSAPLRQ ANPTEGYDDL YLDTIDRQVL DFDFEKLCSI SLSNINVYAC LVCGKYFQGR
     GPKSHAYFHA LDEDHHVFIN LETQKVYVLP EGYEVKSKSL DDIKYVSDPR YTKREVMSLD
     RSHHKSWTLA GKEYTPGFVG MNNIKENDYL NVIVQALSHV PPLRNYFLLE DFTKTTELVK
     RCSILFRKIW NPRAFKAHVS PHELLQEIAL RSNKRFTLTT QSDPVEFLSW FLNNLHLGLG
     GSRSKPGSSM IQRTFQGRLK VESQAITARA DATDRLRFEE AAQVKVDIVR FLLLTLDLPA
     APLFQDELER NIIPQVPLTT ILSKYDGKSA QEHHAQRKRY RLLHPLPPYL IFHVKRFSQN
     KFVSERNPTI VTFDARNLDV SPYVEPNPAE WPASEPIWYD LVANVVHEAV RTREDVADSG
     DERKTWKAQV RDRATGEWVS CQDLYVEKVQ SELLYLGETY LQIWERRREP KPAASGARNK
     VMA
//