ID E9E9I2_METAQ Unreviewed; 743 AA.
AC E9E9I2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=MAC_06530 {ECO:0000313|EMBL:EFY87422.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY87422.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY87422.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
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DR EMBL; GL698527; EFY87422.1; -; Genomic_DNA.
DR RefSeq; XP_007812870.1; XM_007814679.1.
DR AlphaFoldDB; E9E9I2; -.
DR STRING; 655827.E9E9I2; -.
DR GeneID; 19250841; -.
DR KEGG; maw:MAC_06530; -.
DR eggNOG; KOG0941; Eukaryota.
DR HOGENOM; CLU_002173_5_4_1; -.
DR InParanoid; E9E9I2; -.
DR OMA; FSSFKCE; -.
DR OrthoDB; 5471864at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EFY87422.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 396..743
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 711
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 743 AA; 83971 MW; 2E05DF18119A5CB9 CRC64;
MKTPNLNWGE LDSWYCLIIN AAEEWFSVYE DVCRESTVRP QTQRDLEILE QELLQGQEHA
QRVLLKATES LLKRPGRPMA NASDVRFLLI IMENPLLHAE FRGFGGILQP DAVAHPPPQV
VSPRRKLLPS SGLLSGQHSG IIKRIIGLIS NTPPECHNQL ITWFSKYDRR RFVRTKDLIS
GFLSYRLLRQ IDKKQPTEVD ITAGLIPEMR AGRSGAGFYL HDEIRTGGAS KKKEPEHKIA
YTEDWQIKAA SRVLALLFAA NSAPGIRHGY STTAAGVNVA AGSTREYGHS SGQLVPTTDF
YNSMIDYADL VSDFESWESK RSKFSFCQYP FLMSIWAKTH ILEHDAKRQM QMKARDAFLD
SIMTNRNVKQ YLSLDVRREC LVEDSLAAVS EVIGSGSEDV KKGLRITFRG EEGIDAGGLR
KEWFLLLIRE VFNPDHGMFL YDEDSQYCYF NPATFETSDQ FFLVGVVMGL AIYNSTILDV
ALPPFAFRKL LAAAPAHGLG MSSRPRPSMQ YTLEDLAEYR PRVARGLRQL LDFEGDVESA
FSLDFVIDTE KYGTTVQVPL CHGGERKAVT NSNRREYVDL YIRYVLDTAV TRQFEPFKRG
FYTVCGGNAF SLFRPEEIEL LIRGSDEALD IASLRAVAEY DNWESRQPDG SSPVVGWFWE
TFQEATPGNQ RKLLSFITGS DRIPATGAAM LPIKISCLGE DVGRYPIART CFNMLSLWRY
GSKQKLEGML WRAVFESEGF GLK
//
