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Database: UniProt
Entry: E9EC93_METAQ
LinkDB: E9EC93_METAQ
Original site: E9EC93_METAQ 
ID   E9EC93_METAQ            Unreviewed;       780 AA.
AC   E9EC93;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   03-JUL-2019, entry version 45.
DE   SubName: Full=Urease {ECO:0000313|EMBL:EFY86477.1};
GN   ORFNames=MAC_07491 {ECO:0000313|EMBL:EFY86477.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY86477.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY86477.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z.,
RA   Hu X., Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W.,
RA   Wang S., Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y.,
RA   Feng M.G., Xia Y., Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRSR:PIRSR611612-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR611612-51};
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR611612-50}.
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DR   EMBL; GL698546; EFY86477.1; -; Genomic_DNA.
DR   RefSeq; XP_007813831.1; XM_007815640.1.
DR   STRING; 92637.XP_007813831.1; -.
DR   EnsemblFungi; EFY86477; EFY86477; MAC_07491.
DR   GeneID; 19251802; -.
DR   KEGG; maw:MAC_07491; -.
DR   InParanoid; E9EC93; -.
DR   KO; K01427; -.
DR   OrthoDB; 183108at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:InterPro.
DR   GO; GO:0043419; P:urea catabolic process; IEA:InterPro.
DR   CDD; cd00375; Urease_alpha; 1.
DR   CDD; cd00407; Urease_beta; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002499};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR611612-51};
KW   Nickel {ECO:0000256|PIRSR:PIRSR611612-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT   DOMAIN      344    780       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    535    535       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       349    349       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       351    351       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       432    432       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       432    432       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       461    461       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       487    487       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       575    575       Nickel 1. {ECO:0000256|PIRSR:PIRSR611612-
FT                                51}.
FT   BINDING     434    434       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     432    432       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR611612-50}.
SQ   SEQUENCE   780 AA;  83220 MW;  93E728230C8412BE CRC64;
     MALGATMLGR RHVLPAVCST LREIQVEGTF PMGTYLVTVH NPIATDDGDL RRALYGSFLP
     VPDTEAFPLP PDSEYALDKQ PGAVVAVRGR VVLNQNRARI RLRVTSKGDR PIQVGSHYHF
     VETNAQLEFD RGRAYGYRLD IAAGTSVRFE PGDTKTVTLV EMGGGRVIRG GTGLAAGIVE
     RRRAADVVAG LQAAGFAHVA EANPRGDAAH IDMFRMDRAA YAAMFGPTTG DLVRLGNTHL
     WIQVERDMTS YGDECKFGGG KTLREGMGQA TGRRDAEALD VVVTNALIVD WTGIYKADIG
     VKDGLIVGIG KAGSPDVMDG VTPNMVVGSC TDVIAAEGKI VTAGGIDTHI HYICPQQANE
     ALASGITTFL GGGTGPSAGS NATTCTPGKN LIRAMLQACD ALPLNVGLTG KGCDSSPEAL
     REQITAGACG LKVHEDWGAT PAAIDACLGV CDELDVQCCI HTDTLNESGF VEQTIAAFKG
     RTIHTYHTEG AGGGHAPDII SVVEHPNVLP ASTNPTRPFT NNTLDEHLDM LMVCHHLSKN
     IPEDVAFAES RIRAETIAAE DVLQDMGAIS IMSSDSQAMG RCGEVVLRTW NTAHKNKLQR
     GKLPEDEASD ADNFRVRRYV SKYTVNPAIA QGFSHLVGSI EVGKLADLVI WDPAWFGTKP
     SFVLKAGMVA WAMMGDANGS IPTIQPTIGR PMYAPLVPST KVLFVSEACI SSGTAASYGL
     RSRVEAVRNC RGIGKKDMRL NDAMPKMKVD PESYVVEADG KVCSAEPAET LPLTQTWYIY
//
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