ID E9EDT7_METAQ Unreviewed; 737 AA.
AC E9EDT7;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Histone deacetylase {ECO:0000256|PIRNR:PIRNR037919};
DE EC=3.5.1.98 {ECO:0000256|PIRNR:PIRNR037919};
GN ORFNames=MAC_08042 {ECO:0000313|EMBL:EFY85896.1};
OS Metarhizium acridum (strain CQMa 102).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN [1] {ECO:0000313|EMBL:EFY85896.1, ECO:0000313|Proteomes:UP000002499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY85896.1,
RC ECO:0000313|Proteomes:UP000002499};
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
CC -!- FUNCTION: Responsible for the deacetylation of lysine residues on the
CC N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone
CC deacetylation gives a tag for epigenetic repression and plays an
CC important role in transcriptional regulation, cell cycle progression
CC and developmental events. {ECO:0000256|PIRNR:PIRNR037919}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:61930; EC=3.5.1.98;
CC Evidence={ECO:0000256|PIRNR:PIRNR037919};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037919}.
CC -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 2
CC subfamily. {ECO:0000256|PIRNR:PIRNR037919}.
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DR EMBL; GL698562; EFY85896.1; -; Genomic_DNA.
DR RefSeq; XP_007814382.1; XM_007816191.1.
DR AlphaFoldDB; E9EDT7; -.
DR STRING; 655827.E9EDT7; -.
DR ESTHER; metaq-e9edt7; Arb2_domain.
DR GeneID; 19252353; -.
DR KEGG; maw:MAC_08042; -.
DR eggNOG; KOG1343; Eukaryota.
DR HOGENOM; CLU_007727_4_0_1; -.
DR InParanoid; E9EDT7; -.
DR OMA; FVSPACY; -.
DR OrthoDB; 124800at2759; -.
DR Proteomes; UP000002499; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031078; F:histone H3K14 deacetylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR019154; Arb2-like_domain.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR017321; Hist_deAcase_II_yeast.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF09757; Arb2; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PIRSF; PIRSF037919; HDAC_II_yeast; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|PIRNR:PIRNR037919};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR037919};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037919};
KW Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW Repressor {ECO:0000256|PIRNR:PIRNR037919};
KW Transcription {ECO:0000256|PIRNR:PIRNR037919};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR037919}.
FT DOMAIN 77..402
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT DOMAIN 455..712
FT /note="Arb2-like"
FT /evidence="ECO:0000259|Pfam:PF09757"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 82287 MW; 9E05D9719021C6F2 CRC64;
MGDADLTNGT SHDNSVRPED DDDTASEEAS YDDGVYPDLQ DLALEQLRRR GLLPTGCCYD
DRMKLHMNAD FSPNTHHPED PRRIHEIFKA FKRAGLVYTG PEAELPKIIK ECPTRYMWRI
PARPATSQEI CLAHSSEHMT WVEHLDKLST AELRELTKRY DQGRESLYVG SMSYPAALLS
AGGAIDTCKN VVAGQVKNAF AVIRPPGHHA EFDAPMGFCF FNNVPVAVRV CQQDYSDICR
KVLVLDWDVH HGNGIQNIFY EDPNVLYISI HVYQNGHFYP GKPPNPETPD GGIENCGAGP
GLGKNINIGW HDQGMGDGEY MAAFQKIIMP IAKEFNPDLV VISAGFDAAD GDELGGCFVT
PPCYAHMTHM LMSLADGKVA VCLEGGYNLS AISSSAVAVA QTLMGEPPPK MTIPKLNKEA
ARTLAKVQAY QAPYWECMRP GIVDVPAVQS LNANRLHDVI RSAQRLVLQE KHNMIPLYVQ
RDQLYKSFEN QVLVTPNLHN SRRMLVIIHD PPQLLAQPDP IDSSLQPHNA WVVDGVTRYI
DWAISQKFGI MDINVPAYIT NDEDTDSYIP GYRERILQEQ VQQLMNYLWD NFLQLYDADE
IFLMGVGNAY LGVKVLLINR DCKSKLSGVV NFVTGNLRPV KSDIDPDLSL WYKENSRVYV
AGDHACWSDH DLTKKVQKRR FGTVIRSPKL GLNKMMQEHA DEVQGWILSR VSATSRGDTT
EEEDEDDGNG IGGVRAG
//
